Category: Assay Notes

Advanced ImmunoChemical is pleased to offer five In vitro produced lipoprotein-associated phospholipase A2 (Lp-PLA2)-specific murine antibodies and recombinant human Lp-PLA2 protein for high performance quantitative immunoassay measurement of Lp-PLA2 in mass units (ng/ml). Download Assay Notes  Four major international societies including the American Heart Association, the European Society of Cardiology, the American College of Cardiology, and the American Society of Endocrinology have … Read more →

Canine parvovirus, type 2 (CPV-2) causes a severe and highly contagious disease in dogs. A common manifestation of parvovirus infection is hemorrhagic enteritis. The disease can be prevented by vaccination and the CPV-2 vaccine is recommended as a core vaccine that should be given to all dogs. Advanced ImmunoChemical now offers recombinant CPV-2 capsid protein … Read more →

Cystatin C is a low molecular weight (13.4 kDa) protein that functions as an inhibitor of various cysteine proteases in the bloodstream. It inhibits both endogenous proteases, such as lysosomal cathepsins, and proteases of parasites and microorganisms. Cystatin C binds to the target molecule in μM to the sub pM range in a competitive reversible … Read more →

Now available: monoclonal antibodies specific to SARS-CoV-2 nucleoprotein in lateral flow. Four anti-SARS-CoV-2 nucleoprotein antibodies are now available from Advanced ImmunoChemical in their final forms: in vivo C518, C525, C706 and C715. In addition, one of our anti-Spike clones, RBD1107, is now available as an in vitro product R107. The antibodies have been tested with COVID-19 positive patient samples. The best pairs in … Read more →

Now available: eleven monoclonal antibodies specific to SARS-CoV-2 Nucleoprotein and three specific to Spike RBD, plus antigens. SARS-CoV-2 is a novel coronavirus causing COVID-19. In March 2020, the World Health Organization announced the COVID-19 outbreak as a pandemic. SARS-CoV-2 belongs to a large family of single-stranded RNA viruses (+ssRNA). Beta-coronaviruses such as SARS-CoVs can cross species … Read more →

Now available: SARS-CoV-2 Spike RBD antigen from Advanced ImmunoChemical. Our recombinant SARS-CoV-2 Spike RBD antigen has been produced in mammalian cells Purity is over 95%. It is provided in lyophilized form and can be used in the development of COVID-19 serology (antibody) tests. SARS-CoV-2 Spike RBD is a fragment Arg319-Phe541 of the spike surface glycoprotein … Read more →

New! The cardiac isoform of Troponin I (cTnI) is used as a gold standard as marker of acute myocardial infarction (AMI). The region 24-40 aar of cTnI is a perspective target for monoclonal antibodies (MAb), because it is less affected by the action of autoantibodies and is not hindered by the other components of troponin … Read more →

Traumatic brain injuries (TBIs), including concussions, are one of the main public health concerns globally. TBI diagnosis is currently based on clinical assessment using scores such as Glasgow coma scale and computer tomography. However, scores can be compromised for various reasons and the computer tomography is less than perfect too as even in severe cases … Read more →

In dogs, C-reactive protein (CRP) can be used as a marker of inflammation. Its concentration in blood increases rapidly in systemic inflammation and decreases quickly during recovery. It has been shown to increase in disorders such as bacterial infections, sepsis and pyometra, as well as in the case of post-surgical infections. The marker responds to … Read more →

In a recent article, researchers at HyTest, Ltd. continued to study the prognostic value of insulin-like growth factor binding protein-4 (IGFBP-4) fragments in cardiac related diseases. The goal of the study was to assess the carboxy-terminal fragment (CT-IGFBP4) for the prognosis of outcomes of patients with acute heart failure. Read below: https://pubmed.ncbi.nlm.nih.gov/31967738/ The study showed … Read more →

Cystatin C is known in clinical practice as a well-described serum marker of renal failure that is not dependent on age, sex or lean muscle mass (4, 5). At the same time, cystatin C is becoming acknowledged as a marker of elevated risk of death from cardiovascular complications – myocardial infarction and stroke (5). A … Read more →

Click here to download the Beta-Amyloid 1–42 Assay Note (PDF). Alzheimer’s disease (AD) is a complex progressive neurodegenerative disease that affects approximately 14 million people in Europe and the United States, including almost one-half of the population aged 85 years and over (43%). Alzheimer’s disease is the most common cause of dementia and it is … Read more →

Advanced ImmunoChemical offers monoclonal antibodies specific to different parts of rat C-peptides I and II. Thoroughly chosen epitopes and original approaches for selecting specific monoclonal antibodies have produced highly sensitive and specific antibodies which make C-peptide detection possible without cross-reactivity with native proinsulin or other known forms of partially processed proinsulin. Moreover we also offer … Read more →