Tyrosine Hydroxylase, Sheep Polyclonal Affinity Purified

Product Information
Anti-Tyrosine Hydroxylase, Sheep. Formulation: Affinity purified, polyclonal antibody. Antigen: Native rat tyrosine hydroxylase, purified from pheochromocytoma. Species reactivity: The antibody recognizes all mammalian and at least some non- mammalian forms of the enzyme in Western blots and in IHC/IF. Biological Significance: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001).  

Description: Anti-Tyrosine Hydroxylase, Sheep. Formulation: Affinity purified, polyclonal antibody. Antigen: Native rat tyrosine hydroxylase, purified from pheochromocytoma. Species reactivity: The antibody recognizes all mammalian and at least some non- mammalian forms of the enzyme in Western blots and in IHC/IF. Biological Significance: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001).  

Specificity: Most mammals, Some invertebrates. Antibody Specificity: Specific for the ~60k tyrosine hydroxylase protein.  

Applications: WB: 1:1000 IF (frozen sections; unpublished observations): 1:1000 IHC (frozen sections; unpublished observations): 1:1000  

Purity: Prepared from sheep serum by affinity purification using a column to which immunogen was coupled. The antibody is predominantly of the IgG subclass.  

Storage Conditions: Blue ice  

Shipping Conditions: For long term storage ?20. Stable at ?20 C for at least 1 year.  

Host Animal: Sheep

Price: $349.00

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