Recent Citations

Abstract Multiple myeloma is a plasma cell malignancy characterized by marked
heterogeneous genomic instability including frequent genetic alterations in epigenetic
enzymes. In particular, the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2 …

Severe bronchospasm refractory to β-agonists is a challenging aspect of asthma therapy
and novel therapeutics are needed. β-agonist-induced airway smooth muscle (ASM)
relaxation is associated with increases in the phosphorylation of the small heat-shock …

Objective: Epidermal growth factor (EGF) receptor (EGFR/HER1) is overexpressed in human
pancreatic cancers. However, anti-EGFR therapy does not exhibit significant therapeutic
activity with oncogenic K-ras mutation. We sought to assess the signaling relationship …

Abstract Francisella tularensis is an infectious, gram-negative, intracellular microorganism,
and the cause of tularemia. Invasion of host cells by intracellular pathogens like Francisella
is initiated by their interaction with different host cell membrane receptors and the rapid …

Background The activity of one of the major catechins in Green Tea, the polyphenol (−)-
epigallocatechin-3-gallate (EGCG), has been shown to have a variety of health benefits.
Recent studies suggest that EGCG can modulate both the innate and adaptive arms of the …

The potential contamination of Toxoplasma gondii and Neospora caninum oocysts in the
human environment is a concern from the public health viewpoint. However, estimation of
their seroprevalences in humans cannot be performed in a manner that distinguishes …

Background Toxoplasma gondii hijacks host cells to allow it to disseminate throughout a
host animal; however, the migratory machinery involved in this process has not been well
characterized. We examined the functional role of T. gondii cyclophilin 18 (TgCyp18) in …

Abstract Initiation of force generation during vascular smooth muscle contraction involves a
rise in intracellular calcium ([Ca 2+] i) and phosphorylation of myosin light chains (MLC).
However, reversal of these two processes alone does not account for the force inhibition …

Background Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies
and has a high mortality rate due to late detection and lack of efficient treatments. Identifying
novel drug targets for this indication may open the way for new treatment strategies. …

↵3 To whom correspondence may be addressed: Pneumococcus Group (PG), Inst. de Biologie
Structurale Jean-Pierre Ebel, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France. Tel.:
33-4-38-78-56-34; Fax: 33-4-38-78-54-94; E-mail: anne-marie.di-guilmi{at}ibs.fr.

Abstract Acyl-CoA thioesterase (Acot) 2 localizes to the mitochondrial matrix and hydrolyses
long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxidative
tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role …

Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is a potent inducer of
apoptosis in Jurkat T lymphoma cells. One of the characteristics of the phase preceding
overt apoptosis is the marked downregulation of protein synthesis. We have investigated …

Summary The apical complex of Toxoplasma gondii enables it to invade virtually all
nucleated cells in warm-blooded animals, including humans, making it a parasite of global
importance. Anti-T. gondii cellular defence mechanisms depend largely on interferon (IFN) …

Abstract Some long non-coding RNAs (lncRNAs) participate in physiological processes that
maintain cellular and tissue homeostasis, and thus, the dysregulated expression of lncRNAs
is involved in the onset and progression of many pathological conditions. Research has …

Abstract Cyclin/cyclin-dependent kinase (CDK) complexes are critical regulators of cellular
proliferation. A complex network of regulatory mechanisms has evolved to control their
activity, including activating and inactivating phosphorylation of the catalytic CDK subunit …

Abstract MECP2 duplication syndrome is a childhood neurological disorder characterized by
intellectual disability, autism, motor abnormalities, and epilepsy. The disorder is caused by
duplications spanning the gene encoding methyl-CpG-binding protein-2 (MeCP2), a …

Abstract Endorepellin, the C-terminal module of perlecan, negatively regulates
angiogenesis counter to its proangiogenic parental molecule. Endorepellin binds α2β1i
integrin on endothelial cells and triggers a signaling cascade that leads to disruption of …

ABSTRACT The vast majority of cellular mRNAs initiate their translations through a well-
defined mechanism of ribosome recruitment that occurs at the 5′-terminal 7-
methylguanosine cap with the help of several canonical protein factors. A subset of …

Objective To the test the hypothesis that exercise training would increase endothelin-
mediated vasoconstriction in collateral-dependent arteries via enhanced contribution of ET
A. Methods An ameroid constrictor was surgically placed around the proximal LCX artery …

Abstract Several reports have previously highlighted the potential role of miR-206 in the post-
transcriptional downregulation of utrophin A in cultured cells. Along those lines, we recently
identified K-homology splicing regulator protein (KSRP) as an important negative …

A method of determining a concentration of analytes of interest in a sample reaction mixture
is disclosed. The method can include measuring intensities of the polarized fluorescence of
at least one comparative reaction mixture containing different, known amounts of the …

Abstract During mitosis the chromatin undergoes dramatic architectural changes with the
halting of the transcriptional processes and evacuation of nearly all transcription associated
machinery from genes and promoters. Molecular bookmarking of genes during mitosis is a …

Abstract Bispecific antibodies (BsAb) have proven to be useful targeting vectors for
pretargeted radioimmunotherapy (PRIT). We sought to overcome key PRIT limitations such
as high renal radiation exposure and immunogenicity (eg, of streptavidin–antibody fusions …

Abstract Despite antiretroviral therapy (ART), HIV infection promotes cognitive dysfunction
and neurodegeneration through persistent inflammation and neurotoxin release from
infected and/or activated macrophages/microglia. Furthermore, inflammation and immune …

Abstract The established causal relationship between the chronic inflammatory
microenvironment, tumor development and cancer recurrence has provided leads for
developing novel preventive strategies. Accumulating experimental, clinical and …

Background Influenza virus remains a significant health and social concern in part because
of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1
vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, …

Abstract Previously, we have shown that focal adhesion kinase (FAK) and insulin-like growth
factor receptor-1 (IGF-1R) directly interact with each other and, thereby, activate crucial
signaling pathways that benefit cancer cells. Inhibition of FAK and IGF-1R function have …

Abstract Chronic myelogenous leukemia (CML) is a myeloproliferative disorder
characterized at the molecular level by the expression of Bcr-Abl, a chimeric protein with
deregulated tyrosine kinase activity. The protein-tyrosine phosphatase 1B (PTP1B) is up- …

↵1 To whom correspondence should be addressed: Dept. of Biomedical Sciences, Cornell
University, Tower Rd., Ithaca, NY 14853-6401. Tel.: 607-253-4443; Fax: 607-253-4212;
E-mail: rsw26{at}cornell.edu. … Background: The 9-1-1 complex mediates checkpoint …

Transforming growth factor b1 (TGF-b1) increases dehydroepiandrosterone (DHEA)
metabolism to androgens and prostatespecific antigen (PSA) in a prostate tissue model
where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) …

Abstract Glycogen synthase kinase-3 (GSK-3) is linked to the pathogenesis of Alzheimer’s
disease (AD), senile plaques (SPs), and neurofibrillary tangles (NFTs), but the specific
contributions of each of the GSK-3 α and β isoforms to mechanisms of AD have not been …

BACKGROUND Prostate cancer (PrCa) risk is positively associated with levels of insulin-like
growth factor I (IGF-I) and prostate specific antigen (PSA), both androgen receptor (AR)
signaling target genes in PrCa cells. Although activated AR is required for androgen- …

Abstract Exercise training has been shown to improve cardiac dysfunction both in patients
and animal models of coronary artery disease; however, the underlying cellular and
molecular mechanisms have not been completely understood. We hypothesized that …

Abstract Prostate specific membrane antigen (PSMA) is overexpressed in prostatic
adenocarcinoma (CaP), and its expression is negatively regulated by androgen stimulation.
However, it is still unclear which factors are involved in this downregulation. TMPRSS2- …

1. An isolated monoclonal antibody that specifically binds to Pseudomonas aeruginosa PcrV
antigen, wherein the antibody comprises a heavy chain (SEQ. ID NO: 2) and a light chain
(SEQ. ID NO: 4) wherein the antibody or a fragment thereof specifically binds to an …

ABSTRACT Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that
utilizes a type III secretion system to subvert host innate immunity. Of the 4 known effector
proteins injected into eukaryotic cells, ExoS and ExoU are cytotoxic. The cytotoxic …