Monoclonal antibodies and antigens for SARS-CoV-2 assay development.

15 Dec, 2020


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Now available: eleven monoclonal antibodies specific to SARS-CoV-2 Nucleoprotein and three specific to Spike RBD, plus antigens.

SARS-CoV-2 is a novel coronavirus causing COVID-19. In March 2020, the World Health Organization announced the COVID-19 outbreak as a pandemic. SARS-CoV-2 belongs to a large family of single-stranded RNA viruses (+ssRNA). Beta-coronaviruses such as SARS-CoVs can cross species barriers and cause in humans illness ranging from a common cold to more severe diseases such as Severe Acute Respiratory Syndorme (SARS, identified in 2003) and Middle East Respiratory Syndrome (MERS, identified in 2012).

COVID-19 related monoclonal antibodies are now available: eleven antibodies specific to SARS-CoV-2 nucleoprotein and three antibodies specific to Spike (RBD). Please note that antibodies are produced as in vivo products. The same antibodies are also available in recombinant or in vitro formats.

Our recombinant SARS-CoV-2 Spike RBD antigen has been produced in mammalian cells. Purity is >95% and is provided in a lyophilized form that can be used for the development of COVID-19 serology (antibody) tests.

SARS-CoV-2 Spike RBD (cat. #8-CoVrbd) is a fragment Arg319-Phe541 of the spikes surface glycoprotein and contains the receptor binding domain of the virus. The protein contains a C-terminal His6-tag.

In addition, we provide monoclonal antibodies specific to different Ig classes: IgM, IgG and IgA which can be used as secondary antibodies in serology assays.

SARS-CoV-2, Nucleoprotein, recombinant (Cat.#8-CoVnp ) is a full-length recombinant antigen that can be used in serology assays for the detection of COVID-19 specific antibodies. The protein has a C-terminal His-tag. It is produced in E. coli and purity of the product is > 95%. The recombinant nucleoprotein is provided in a lyophilized form.


Cat. #8-CoVnp. SARS-CoV-2, Nucleoprotein, recombinant

Cat. #8-CoVrbd. SARS-CoV-2 Spike RBD, mammalian recombinant

Cat. 1-A1iv. Monoclonal Anti-IgA, in vitro

Cat. #1-G1iv. Monoclonal Anti-IgG, in vitro

Cat. #1-M1iv. Monoclonal Anti-IgM, in vitro

Cat. #5-CVs. Monoclonal Anti-SARS-CoV-2, Spike

Cat. #5-CVnp. Monoclonal Anti-SARS-CoV-2, Nucleoprotein

Browse our products and order online:

At Advanced ImmunoChemical, Inc., we provide ISO-9001 manufactured antibodies, viral antigens, recombinant proteins, and PCR enzymes. Our company is an important critical raw material supplier to the IVD industry, government, and academia. Since 1986, our mission has been to help close the gap between biomarker discovery and meaningful clinical use that paves the way to improved patient outcomes.

Advanced ImmunoChemical is open and business continues as normal. We confirm that we are continuing to supply our products as normal and do not foresee any significant disruption in product availability or ship schedules. However, circumstances can change. Please know we will continue to follow developments and do our best to advise you as soon as possible if the situation changes.

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