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New D-dimer monoclonal antibodies (DD189 and DD255) allow for development of an improved immunoassay to detect D-dimer. Elevated levels of D-dimer are found in the blood of patients with pulmonary embolism, deep vein thrombosis and atherosclerosis. D-dimer diagnostic tests are widely used to exclude the diagnosis of deep vein thrombosis. In addition, increased amount of D-dimer … Read more →

Open full PDF Procalcitonin AssayNotes Procalcitonin (PCT) is a small protein (~13 kDa) that is synthesized by the C-cells of the thyroid glands. It is considered to be the main marker of disorders that are accompanied by systemic inflammation and sepsis. PCT is encoded by the CALC-1 gene and it is the precursor of the … Read more →

Tumor biomarkers play a crucial role in monitoring of response to therapy and in post-treatment surveillance of various gastrointestinal and gynecological malignancies. While the clinical value of FDA-approved tumor markers such as CEA, CA19-9 and CA125 has been established, adequate data to support FDA approval of CA72-4 as a potential biomarker are lacking and its … Read more →

Coming soon: Anti-Müllerian Hormone MAbs and Recombinant Protein. Anti-Müllerian hormone (AMH) is increasingly utilized as a biomarker of women’s reproductive health. AMH levels correlate to the size of the follicle pool. In addition, it can be used to assess the response of in vitro fertility treatment. Anti-Mullerian Hormone (AMH) is expressed by granulosa cells. Production declines when follicles … Read more →

Open full PDF High-sensitivity CRP AssayNotes. C-reactive protein (CRP) was originally discovered by Tillett and Francis in 1930 as a substance in the serum of patients with acute inflammation that reacted with the C polysaccharide of pneumococcus. CRP is a 224 residue protein with a monomer molecular mass about 25 kDa and pI 6.4. Monomers are … Read more →

Open PDF Human Papillomavirus (HPV) AssayNotes Human papillomavirus (HPV) belongs to Papillomaviruses, a diverse group of DNA-based viruses that infect the skin and mucous membranes of humans and a variety of animals. Over 100 different human papillomavirus (HPV) types have been identified on the basis of difference in the virus genome nucleotide sequences (e.g. type … Read more →

Properties Description: SmarTaq DNA Polymerase is complex mixture of a thermostable 94 kDa BioTaq DNA Polymerase purified from E. coli PVG-AI recombinant strain expressing Thermus aquaticus polymerase gene and specific monoclonal antibodies. SmarTaq from Advanced ImmunoChemical, Inc. is inactive under conditions of amplification reaction preparation. It provides improved specificity when compared to standard DNA polymerases. SmarTaq can eliminate amplification artifacts such … Read more →

Osteocalcin AssayNotes: Open full PDF Osteocalcin AssayNotes Osteocalcin (OC), which is also known as bone Glaprotein (BGP), is a vitamin K-dependent bone matrix peptide of 49 amino acid residues. The concentration of OC in serum is considered to be an index of bone formation and numerous immunoassays for the measurement of OC have been developed in … Read more →

Advanced ImmunoChemical offers five In vitro produced lipoprotein-associated phospholipase A2 (Lp-PLA2)-specific murine antibodies and recombinant human Lp-PLA2 protein for high performance quantitative immunoassay measurement of Lp-PLA2 in mass units (ng/ml). Click here: view Lp-PLA2 product performance information. Four major international societies including the American Heart Association, the European Society of Cardiology, the American College of Cardiology, and the American Society of Endocrinology … Read more →

Cystatin C AssayNotes Open full Cystatin C AssayNotes pdf. Cystatin C is a low molecular weight (13.4 kDa) cytoplasmic protein functioning as an inhibitor of various cystein proteases in the bloodstream. It inhibits both endogenous proteases, such as lysosomal cathepsines, and proteases of parasites and microbes. Cystatin C binds to the target molecule in µM … Read more →

Open full Procalcitonin AssayNotes pdf file Procalcitonin (PCT) is a small protein (~13 kDa) that is synthesized by the C-cells of the thyroid glands. It is considered to be the main marker of disorders that are accompanied by systemic inflammation and sepsis. PCT is encoded by the CALC-1 gene and it is the precursor of … Read more →

Open full D-dimer AssayNotes. D-Dimer and High Molecular Weight Fibrin Degradation Products Fibrinogen is a blood protein from which fibrin clots are formed upon blood coagulation or thrombotic process. Fibrinogen consists of two identical subunits that contain three polypeptide chains: α, β, and γ. During blood coagulation fibrinogen is first converted into fibrin by thrombin, … Read more →

Serum amyloid A (SAA) is often used as a non-specific marker of inflammation. Its concentration in blood increases in response to inflammatory stimulus such as tissue injury, infection or trauma. SAA proteins are encoded by four different genes, SAA1-SAA4. In human beings, SAA1 and SAA2 belong to the group of major acute phase proteins similarly to … Read more →

Heart failure is a severe health problem that is characterized by an increasing prevalence and economic cost. According to the American Heart Association, in the United States nearly one million new cases are reported each year. BNP and NT-proBNP are established diagnostic and prognostic biomarkers of heart failure. The clinical values of these markers are similar and … Read more →

Cardiovascular diseases are a group of disorders that occur in the heart and blood vessels and are the world’s leading cause of death. Researchers are currently studying whether tests that detect levels of cardiac troponin I (cTnI) in the blood my help physicians diagnose heart attacks sooner. For over 20 years, Advanced ImmuunoChemical, Inc. has been at … Read more →