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MAb pairs to Interleukin-6: distinguish severity of inflammation and prognosis of COVID-19

17 Oct, 2021

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Various biomarkers, especially inflammatory markers like C-reactive protein (CRP), ferritin, fibrinogen, D-dimer and Interleukin 6 (IL-6) are associated with Covid-19 progression. And cytokine-mediated inflammation, also described as cytokine storm, plays an important role in severe cases of COVID-19 and is reported as a major cause of death. IL-6 is produced by the stromal cells and … Read more

D-dimer: biomarker of pathological coagulation in patients with COVID-19

17 Oct, 2021

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New Recommended MAb Pairs D-dimer has been commonly elevated in patients with SARS-CoV-2. It has been shown to correlate with disease severity and to be a reliable prognostic marker for hospitalization and mortality assessment in patients admitted for COVID-19. Elevated levels of D-dimer have been found in the blood of patients with pulmonary embolism (PE) … Read more

New MAb Pairs to Interleukin-6 (IL-6)

14 Oct, 2021

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Interleukin-6 (IL-6) has been shown to be involved in many physiologic activities, disease initiation and progression and the pleiotropic nature of this cytokine makes it a key player in many physiologic processes (1). Serum IL-6 levels have also upregulated during recent outbreaks of coronavirus and are associated with severity of COVID-19 infection (2). IL-6 could … Read more

Neutrophil Gelatinase-assoc Lipocalin (NGAL): promising biomarker of acute kidney injury

17 Apr, 2021

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NGAL (neutrophil gelatinase-associated lipocalin) is a small glycoprotein found in blood and urine. It is expressed by kidney tubular cells after kidney injury and it has been indicated as a promising biomarker of acute kidney injury. In addition, NGAL concentration is known to increase in severe infections. New product. At Advanced ImmunoChemical, we provide several mouse and … Read more

COVID-19 Update: UK and South African Variants

1 Apr, 2021

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Advanced ImmunoChemical now has available anti-SARS-CoV-2 nucleoprotein monoclonal antibodies (anti-SC-NP) that are expected to detect both the United Kingdom and South African variants of SARS-CoV-2. The UK variant of SARS-CoV-2 (known as VOC 202012/01, lineage B.1.1.7, or 20B/501Y.V1) has two mutations in the nucleoprotein: D3L and S235F. The epitope specificities of our key anti-SC-NP monoclonal antibodies: … Read more

Pair recommendations for SARS-CoV-2 antibodies in lateral flow

5 Jan, 2021

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Now available: monoclonal antibodies specific to SARS-CoV-2 nucleoprotein in lateral flow. Four anti-SARS-CoV-2 nucleoprotein antibodies are now available from Advanced ImmunoChemical in their final forms: in vivo C518, C525, C706 and C715. In addition, one of our anti-Spike clones, RBD1107, is now available as an in vitro product R107. The antibodies have been tested with COVID-19 positive patient samples. The best pairs in … Read more

Monoclonal antibodies and antigens for SARS-CoV-2 assay development.

15 Dec, 2020

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Now available: eleven monoclonal antibodies specific to SARS-CoV-2 Nucleoprotein and three specific to Spike RBD, plus antigens. SARS-CoV-2 is a novel coronavirus causing COVID-19. In March 2020, the World Health Organization announced the COVID-19 outbreak as a pandemic. SARS-CoV-2 belongs to a large family of single-stranded RNA viruses (+ssRNA). Beta-coronaviruses such as SARS-CoVs can cross species … Read more

Now available: SARS-CoV-2 Spike RBD

17 Nov, 2020

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Now available: SARS-CoV-2 Spike RBD antigen from Advanced ImmunoChemical. Our recombinant SARS-CoV-2 Spike RBD antigen has been produced in mammalian cells Purity is over 95%. It is provided in lyophilized form and can be used in the development of COVID-19 serology (antibody) tests. SARS-CoV-2 Spike RBD is a fragment Arg319-Phe541 of the spike surface glycoprotein … Read more

Recombinant Rb Cardiac Troponin I Antibodies (cTnI): targeted to epitope region 24-40 a.a.r. of cTnI.

27 Oct, 2020

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New! The cardiac isoform of Troponin I (cTnI) is used as a gold standard as marker of acute myocardial infarction (AMI). The region 24-40 aar of cTnI is a perspective target for monoclonal antibodies (MAb), because it is less affected by the action of autoantibodies and is not hindered by the other components of troponin … Read more

New! GFAP Antibodies: differentiate hemorrhagic versus ischemic stroke

24 Sep, 2020

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Traumatic brain injuries (TBIs), including concussions, are one of the main public health concerns globally. TBI diagnosis is currently based on clinical assessment using scores such as Glasgow coma scale and computer tomography. However, scores can be compromised for various reasons and the computer tomography is less than perfect too as even in severe cases … Read more

New! Polyclonal Antibodies to Canine CRP: marker of systemic inflammation

4 Sep, 2020

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In dogs, C-reactive protein (CRP) can be used as a marker of inflammation. Its concentration in blood increases rapidly in systemic inflammation and decreases quickly during recovery. It has been shown to increase in disorders such as bacterial infections, sepsis and pyometra, as well as in the case of post-surgical infections. The marker responds to … Read more

CT-IGFBP-4 as a Novel Prognostic Biomarker in Acute Heart Failure

21 Aug, 2020

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In a recent article, researchers at HyTest, Ltd. continued to study the prognostic value of insulin-like growth factor binding protein-4 (IGFBP-4) fragments in cardiac related diseases. The goal of the study was to assess the carboxy-terminal fragment (CT-IGFBP4) for the prognosis of outcomes of patients with acute heart failure. Read below: https://pubmed.ncbi.nlm.nih.gov/31967738/ The study showed … Read more

Major Predictors of COVID-19 Severity

11 Apr, 2020

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New. Biomarkers to screen for mysterious heart damage and other health issues befalling some COVID-19 patients. Testing for SARS-CoV-2 is not the only requirement in regards to managing COVID-19. Screening and monitoring for the various health issues that may arise as part of COVID-19 disease management are also needed. You can find the following biomarkers in … Read more

MAbs for COVID-19 Etiological and Serological Examination

11 Apr, 2020

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Monoclonal Antibodies for Development of COVID-19 Serology Assays  To detect and measure the levels of SARS-CoV-2 antibodies as a result of exposure to COVID-19 will provide valuable information on the development of individual immunity. COVID-19 specific IgM antibodies can be detected after 3-5 days from onset of the disease. IgG antibodies appear later, however, their … Read more

Beta-Amyloid 1–42 Assay Note

22 Aug, 2019

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Click here to download the Beta-Amyloid 1–42 Assay Note (PDF). Alzheimer’s disease (AD) is a complex progressive neurodegenerative disease that affects approximately 14 million people in Europe and the United States, including almost one-half of the population aged 85 years and over (43%). Alzheimer’s disease is the most common cause of dementia and it is … Read more

Canine C-reactive protein is a marker of systemic inflammation.

25 Jun, 2019

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Canine C-reactive protein (cCRP) is a major acute phase protein in dogs. Its concentration increases rapidly and significantly during systemic inflammation and subsequently decreases quickly following the elimination of the source of inflammation. Several studies support the view that cCRP is a valuable diagnostic marker for the detection of the acute phase response in dogs. Its … Read more

New D-dimer monoclonal antibodies: improved immunoassay equally specific for FDPs and D-dimer.

5 Feb, 2019

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New D-dimer monoclonal antibodies (DD189 and DD255) allow for development of an improved immunoassay to detect D-dimer. Elevated levels of D-dimer are found in the blood of patients with pulmonary embolism, deep vein thrombosis and atherosclerosis. D-dimer diagnostic tests are widely used to exclude the diagnosis of deep vein thrombosis. In addition, increased amount of D-dimer … Read more

New! Recombinant Canine Parvovirus VP2 Protein

6 Dec, 2018

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Canine parvovirus, type 2 (CPV-2) causes a severe and highly contagious disease in dogs. A common manifestation of parvovirus infection is hemorrhagic enteritis. The disease can be prevented by vaccination and the CPV-2 vaccine is recommended as a core vaccine that should be given to all dogs. Advanced ImmunoChemical now offers recombinant CPV-2 capsid protein … Read more

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