Serum amyloid A (SAA) is often used as a non-specific marker of inflammation. Its concentration in blood increases in response to inflammatory stimulus such as tissue injury, infection or trauma. SAA proteins are encoded by four different genes, SAA1-SAA4. In human beings, SAA1 and SAA2 belong to the group of major acute phase proteins similarly to … Read more
Heart failure is a severe health problem that is characterized by an increasing prevalence and economic cost. According to the American Heart Association, in the United States nearly one million new cases are reported each year. BNP and NT-proBNP are established diagnostic and prognostic biomarkers of heart failure. The clinical values of these markers are similar and … Read more
Cardiovascular diseases are a group of disorders that occur in the heart and blood vessels and are the world’s leading cause of death. Researchers are currently studying whether tests that detect levels of cardiac troponin I (cTnI) in the blood my help physicians diagnose heart attacks sooner. For over 20 years, Advanced ImmuunoChemical, Inc. has been at … Read more
Feline, Canine and Equine Serum Amyloid A (SAA) AssayNotes Serum amyloid A (SAA) is a major acute phase protein in many species including humans beings, dogs, cats and horses. The level of SAA proteins in blood increases within just a few hours following the onset of various inflammatory stimuli. These include infection, trauma and surgery. … Read more
New. Anti-BNP Antibodies Advanced ImmunoChemical announces three new monoclonal antibodies specific to BNP. BNP is an established cardiac biomarker and used as a diagnostic and prognostic marker of heart failure. We now provide eight MAbs specific to BNP as shown in Figure 1. Figure 1. New MAbs, 100cc, 130cc and 429cc for use in combination … Read more
Click here to download full article: HbA1c- the Glycated Isoform of Hemoglobin AssayNotes Diabetes is one of the most challenging health problems in the 21st century and it is among leading causes of death in most developed economies but alarmingly also in developing economies. Diabetes causes substantial health costs because of complications often associated with … Read more
Retinol-binding protein (RBP4) TechNotes Open full PDF AssayNotes for RBP4. New. Advanced ImmunoChemical offers a set of mouse monoclonal anti-human RBP4 antibodies suitable for development of sandwich immunoassays for quantitative detection of circulating RBP4 in human plasma as well as for immunodetection of RBP4 in: direct ELISA, Western blotting, or to for immunoprecipitation of the antigen. … Read more
Canine parvovirus, type 2 (CPV-2) causes a severe and highly contagious disease in dogs. A common manifestation of parvovirus infection is hemorrhagic enteritis. The disease can be prevented by vaccination and the CPV-2 vaccine is recommended as a core vaccine that should be given to all dogs. Advanced ImmunoChemical now offers recombinant CPV-2 capsid protein … Read more
New! Advanced ImmunoChemical, Inc. now offers Adiponectin antibodies with properties that detect LMW, HMW or total Adiponectin for assay development and research (1). In addition, we also provide purified native Adiponectin that can be used as a calibrator for Adiponectin immunoassays. As obesity and metabolic syndrome have become global health burdens, there is an increasing need to … Read more
Advanced ImmunoChemical offers monoclonal antibodies specific to different parts of rat C-peptides I and II. Thoroughly chosen epitopes and original approaches for selecting specific monoclonal antibodies have produced highly sensitive and specific antibodies which make C-peptide detection possible without cross-reactivity with native proinsulin or other known forms of partially processed proinsulin. Moreover we also offer … Read more
New Products: Canine TSH MAbs and Recombinant Antigen Hypothyroidsim is one of the most frequent canine endocrine disorders. The diagnosis of hypothyroidism is based on the presence of clinical signs, thyroid function test results and response to the thyroid hormone replacement therapy. A low circulating total T4 concentration suggests hypothyroidism. However, in order to reliably evaluate … Read more
Brain natriuretic peptide (BNP) and the N-terminal part of the BNP precursor proBNP (NT-proBNP) are established diagnostic and prognostic biomarkers of heart failure (HF). HF is a severe clinical and public health problem that is characterized by an increasing prevalence and economic cost. Chronic heart disease, hypertension and diabetes are among the known risk factors … Read more
The cardiac isoform of TnT is widely used as a marker of myocardial cell injury, just as cTnI is. cTnT has the same release kinetics into the bloodstream and the same sensitivity for minor myocardial injury as cTnI. In the blood of acute myocardial infarction (AMI) patients, cTnT is often found in a free form … Read more
CRP is a 224 a.a.r. protein with molecular mass of approximately 25 kDa and a pI = 6.4 for each monomer (1). Native pentameric protein is predominantly found in plasma as a calcium dependent ligand bound by radial symmetry of five monomers forming a ring around a central core (2). High-sensitivity C-reactive protein (hsCRP) is … Read more
Heterophile antibodies arise when people are exposed to different animals or products derived from animals. These antibodies are typically human anti-mouse (HAMA), anti-rabbit, anti-goat, anti-sheep, anti-cow, anti-pig, anti-rat or anti-horse. As far as immunodiagnostics is concerned, the problem is most commonly associated with HAMA due to the fact that most diagnostics assays use mouse derived … Read more
It is well known that kidney injuries can tend to accompany many severe illnesses such as cardiac diseases, trauma and sepsis, and is an increasingly common and devastating complication in hospitalized patients. Despite improvements in health outcomes in many areas during recent years, mortality and morbidity rates associated with acute kidney injury (AKI) remain very … Read more
Acute phase proteins (APPs) constitute a group of proteins whose blood concentration changes rapidly in response to stressors such as infection and tissue damage. C-reactive protein (CRP) is a representative APP with synthesis in hepatocytes greatly increasing during systemic inflammation and in various disorders including viral and bacterial infections, sepsis and surgical trauma (1-3). Advanced … Read more
Gangliosides are a large group of sialylated glycosphingolipids that are widely expressed in mammalian tissues and are particularly abundant in brain and nervous tissues. The differential distribution of gangliosides in various tissues is a strong indication they play important roles in specific functions in different tissues. Gangliosides as a full product line are now available … Read more
Heart-type fatty acid binding protein (H-FABP) is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode. H-FABP is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation (1). Click here to view H-FABP AssayNotes and product information. Diagnostic potential: H-FABP … Read more
Adiponectin is an abundant hormone secreted by adipocytes. It appears to have many functions in organisms, however, the main function of adiponectin is most likely the regulation of glucose metabolism. Adiponectin is an insulin-sensitizing hormone that has been extensively studied as a prognostic and diagnostic marker of diabetes and cardiovascular diseases. Low blood adiponectin levels … Read more