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Update: December 01, 2021 Anti-SARS-CoV-2 nucleoprotein antibodies Anti-SARS-CoV-2 nucleoprotein antibodies (Cat.# 5-CVnp, MAbs C518, C524, C527, C706, C715) bind to the N-terminal part of the nucleoprotein: N47-A173. Several mutations found in circulating SARS-CoV-2 variants are located outside of this region however. Thus, it is important to test all relevant and concerning mutations regardless of their … Read more →

Various biomarkers, especially inflammatory markers like C-reactive protein (CRP), ferritin, fibrinogen, D-dimer and Interleukin 6 (IL-6) are associated with Covid-19 progression. And cytokine-mediated inflammation, also described as cytokine storm, plays an important role in severe cases of COVID-19 and is reported as a major cause of death. IL-6 is produced by the stromal cells and … Read more →

New Recommended MAb Pairs D-dimer has been commonly elevated in patients with SARS-CoV-2. It has been shown to correlate with disease severity and to be a reliable prognostic marker for hospitalization and mortality assessment in patients admitted for COVID-19. Elevated levels of D-dimer have been found in the blood of patients with pulmonary embolism (PE) … Read more →

Interleukin-6 (IL-6) has been shown to be involved in many physiologic activities, disease initiation and progression and the pleiotropic nature of this cytokine makes it a key player in many physiologic processes (1). Serum IL-6 levels have also upregulated during recent outbreaks of coronavirus and are associated with severity of COVID-19 infection (2). IL-6 could … Read more →

NGAL (neutrophil gelatinase-associated lipocalin) is a small glycoprotein found in blood and urine. It is expressed by kidney tubular cells after kidney injury and it has been indicated as a promising biomarker of acute kidney injury. In addition, NGAL concentration is known to increase in severe infections. New product. At Advanced ImmunoChemical, we provide several mouse and … Read more →

Advanced ImmunoChemical now has available anti-SARS-CoV-2 nucleoprotein monoclonal antibodies (anti-SC-NP) that are expected to detect both the United Kingdom and South African variants of SARS-CoV-2. The UK variant of SARS-CoV-2 (known as VOC 202012/01, lineage B.1.1.7, or 20B/501Y.V1) has two mutations in the nucleoprotein: D3L and S235F. The epitope specificities of our key anti-SC-NP monoclonal antibodies: … Read more →

New. Biomarkers to screen for mysterious heart damage and other health issues befalling some COVID-19 patients. Testing for SARS-CoV-2 is not the only requirement in regards to managing COVID-19. Screening and monitoring for the various health issues that may arise as part of COVID-19 disease management are also needed. You can find the following biomarkers in … Read more →

Monoclonal Antibodies for Development of COVID-19 Serology Assays  To detect and measure the levels of SARS-CoV-2 antibodies as a result of exposure to COVID-19 will provide valuable information on the development of individual immunity. COVID-19 specific IgM antibodies can be detected after 3-5 days from onset of the disease. IgG antibodies appear later, however, their … Read more →

Canine C-reactive protein (cCRP) is a major acute phase protein in dogs. Its concentration increases rapidly and significantly during systemic inflammation and subsequently decreases quickly following the elimination of the source of inflammation. Several studies support the view that cCRP is a valuable diagnostic marker for the detection of the acute phase response in dogs. Its … Read more →

New D-dimer monoclonal antibodies (DD189 and DD255) allow for development of an improved immunoassay to detect D-dimer. Elevated levels of D-dimer are found in the blood of patients with pulmonary embolism, deep vein thrombosis and atherosclerosis. D-dimer diagnostic tests are widely used to exclude the diagnosis of deep vein thrombosis. In addition, increased amount of D-dimer … Read more →

Open full PDF Procalcitonin AssayNotes Procalcitonin (PCT) is a small protein (~13 kDa) that is synthesized by the C-cells of the thyroid glands. It is considered to be the main marker of disorders that are accompanied by systemic inflammation and sepsis. PCT is encoded by the CALC-1 gene and it is the precursor of the … Read more →