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Kidney Injury Molecule-1 (KIM-1): early diagnostic urinary marker

7 Jun, 2017

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It is well known that kidney injuries can tend to accom­pany many severe illness­es such as cardiac diseas­es, trauma and sepsis, and is an increasingly common and devastating compli­cation in hospitalized pa­tients. Despite improve­ments in health outcomes in many areas during recent years, mortality and morbidity rates asso­ciated with acute kidney injury (AKI) remain very … Read more

Canine C-reactive Protein (cCRP): biomarker for systemic inflammation and tissue damage, particularly in neoplastic and immune-mediated diseases.

10 May, 2017

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Acute phase proteins (APPs) constitute a group of proteins whose blood concentration changes rapidly in response to stressors such as infection and tissue damage. C-reactive protein (CRP) is a representative APP with synthesis in hepatocytes greatly increasing during systemic inflammation and in various disorders including viral and bacterial infections, sepsis and surgical trauma (1-3). Advanced … Read more

Gangliosides: distribution in brain and nervous tissues indicates important roles with cell external ligands and membrane components.

2 May, 2017

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Gangliosides are a large group of sialylated glycosphingolipids that are widely expressed in mammalian tissues and are particularly abundant in brain and nervous tissues. The differential distribution of gangliosides in various tissues is a strong indication they play important roles in specific functions in different tissues. Gangliosides as a full product line are now available … Read more

Heart-type fatty acid binding protein (H-FABP): early marker of acute cardiac syndrome and risk stratification in pulmonary embolism.

1 May, 2017

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Heart-type fatty acid binding protein (H-FABP) is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode. H-FABP is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation (1). Click here to view H-FABP AssayNotes and product information. Diagnostic potential: H-FABP … Read more

Biomarkers for R&D of type 2 diabetes and cardiovascular diseases: adiponectin et. al.

24 Apr, 2017

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Adiponectin is an abundant hormone secreted by adipocytes. It appears to have many functions in organisms, however, the main function of adiponectin is most likely the regulation of glucose metabolism. Adiponectin is an insulin-sensitizing hormone that has been extensively studied as a prognostic and diagnostic marker of diabetes and cardiovascular diseases. Low blood adiponectin levels … Read more

Detecting pathogens and toxins transmitted to humans and vertebrates via contaminated food and water: Caliciviridae (norovirus) et al.

6 Apr, 2017

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Advanced ImmunoChemical, Inc. offers 5 different high quality monoclonal antibodies (MAbs) for the detection of caliciviruses. The antibodies were developed using feline calicivirus (FCV) and rabbit hemorrhagic disease virus (RHDV) as immunogens in order to obtain antibodies that would detect the most common epitopes of different caliciviruses. All MAbs detect human norovirus, feline calicivirus and … Read more

5-minute GAPDH immunodetection for Western blotting and protein normalization from Advanced ImmunoChemical.

25 Mar, 2017

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Here we announce a direct MAb 6C5-HRP conjugate in place of secondary antibodies plus a GAPDH loading control for Western blots and protein normalization available online. Click here: GAPDH Western blot Set. GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is one of the key enzymes involved in glycolysis, catalyzing the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate. Besides functioning as a … Read more

Myeloperoxidase (MPO): inflammation marker that can serve as cardiac marker.

16 Feb, 2017

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Here at Advanced ImmunoChemical, Inc., we announce a new generation of anti-MPO monoclonal antibodies suitable for the development of quantitative MPO immunoassay. Sandwich immunoassays utilizing these antibodies demonstrated exceptionable results in precise MPO immunodetection in patient’s blood samples as shown in our AssayNotes: Click here for Myeloperoxidase AssayNotes and product information. MPO causes oxidative modification … Read more

Urine RBP4: best biomarker of impaired renal proximal tubule function and risk stratification of insulin-resistant patients.

24 Jan, 2017

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Urine retinol-binding protein4 (RBP4), a carrier protein for vitamin A in plasma, is arguably the most sensitive biomarker of human proximal renal tubular function known. Advanced ImmunoChemical is pleased to offer anti-human RBP4 monoclonal antibodies, as well as purified endogenous RBP4 for quantitative detection of circulating RBP4. Urine RBP4 AssayNotes and product information. Impaired tubule … Read more

Article about cTnI autoantibodies and what they tell us about circulating troponins- Courtesy of HyTest, Ltd.

20 Jan, 2017

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Research Courtesy of HyTest, Ltd.  The presence of cardiac troponin I autoantibodies in blood has been known for a long time. These autoantibodies bind to the stable part of cTnI and may be found in the blood of both healthy people and people with different diseases. They may interfere with the cTnI tests if the … Read more

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