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Canine thyroid stimulating hormone (TSH, thyrotropin): biomarker to reliably evaluate thyroid function

5 Dec, 2017

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New Products: Canine TSH MAbs and Recombinant Antigen Hypothyroidsim is one of the most frequent canine endocrine disorders. The diagnosis of hypothyroidism is based on the presence of clinical signs, thyroid function test results and response to the thyroid hormone replacement therapy. A low circulating total T4 concentration suggests hypothyroidism. However, in order to reliably evaluate … Read more

Human proBNP, BNP and NT-proBNP: diagnostic and prognostic biomarker of heart failure.

28 Nov, 2017

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Brain natriuretic peptide (BNP) and the N-terminal part of the BNP precursor proBNP (NT-proBNP) are established diagnostic and prognostic biomarkers of heart failure (HF). HF is a severe clinical and public health problem that is characterized by an increasing prevalence and economic cost. Chronic heart disease, hypertension and diabetes are among the known risk factors … Read more

High Sensitivity Human C-reactive Protein: strong serum inflammatory marker and predictor of cardiovascular events without known cardiac disease.

10 Oct, 2017

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CRP is a 224 a.a.r. protein with molecular mass of approximately 25 kDa and a pI = 6.4 for each monomer (1). Native pentameric protein is predominantly found in plasma as a calcium dependent ligand bound by radial symmetry of five monomers forming a ring around a central core (2). High-sensitivity C-reactive protein (hsCRP) is … Read more

Chimeric Cardiac Troponin I Antibodies: early biomarker of AMI without heterophile antibody effect.

6 Sep, 2017

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Heterophile antibodies arise when people are exposed to different animals or products derived from animals. These antibodies are typically human anti-mouse (HAMA), anti-rabbit, anti-goat, anti-sheep, anti-cow, anti-pig, anti-rat or anti-horse. As far as immunodiagnostics is concerned, the problem is most commonly associated with HAMA due to the fact that most diagnostics assays use mouse derived … Read more

Kidney Injury Molecule-1 (KIM-1): early diagnostic urinary marker

7 Jun, 2017

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It is well known that kidney injuries can tend to accom­pany many severe illness­es such as cardiac diseas­es, trauma and sepsis, and is an increasingly common and devastating compli­cation in hospitalized pa­tients. Despite improve­ments in health outcomes in many areas during recent years, mortality and morbidity rates asso­ciated with acute kidney injury (AKI) remain very … Read more

Canine C-reactive Protein (cCRP): biomarker for systemic inflammation and tissue damage, particularly in neoplastic and immune-mediated diseases.

10 May, 2017

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Acute phase proteins (APPs) constitute a group of proteins whose blood concentration changes rapidly in response to stressors such as infection and tissue damage. C-reactive protein (CRP) is a representative APP with synthesis in hepatocytes greatly increasing during systemic inflammation and in various disorders including viral and bacterial infections, sepsis and surgical trauma (1-3). Advanced … Read more

Gangliosides: distribution in brain and nervous tissues indicates important roles with cell external ligands and membrane components.

2 May, 2017

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Gangliosides are a large group of sialylated glycosphingolipids that are widely expressed in mammalian tissues and are particularly abundant in brain and nervous tissues. The differential distribution of gangliosides in various tissues is a strong indication they play important roles in specific functions in different tissues. Gangliosides as a full product line are now available … Read more

Heart-type fatty acid binding protein (H-FABP): early marker of acute cardiac syndrome and risk stratification in pulmonary embolism.

1 May, 2017

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Heart-type fatty acid binding protein (H-FABP) is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode. H-FABP is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation (1). Click here to view H-FABP AssayNotes and product information. Diagnostic potential: H-FABP … Read more

Biomarkers for R&D of type 2 diabetes and cardiovascular diseases: adiponectin et. al.

24 Apr, 2017

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Adiponectin is an abundant hormone secreted by adipocytes. It appears to have many functions in organisms, however, the main function of adiponectin is most likely the regulation of glucose metabolism. Adiponectin is an insulin-sensitizing hormone that has been extensively studied as a prognostic and diagnostic marker of diabetes and cardiovascular diseases. Low blood adiponectin levels … Read more

Detecting pathogens and toxins transmitted to humans and vertebrates via contaminated food and water: Caliciviridae (norovirus) et al.

6 Apr, 2017

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Advanced ImmunoChemical, Inc. offers 5 different high quality monoclonal antibodies (MAbs) for the detection of caliciviruses. The antibodies were developed using feline calicivirus (FCV) and rabbit hemorrhagic disease virus (RHDV) as immunogens in order to obtain antibodies that would detect the most common epitopes of different caliciviruses. All MAbs detect human norovirus, feline calicivirus and … Read more

5-minute GAPDH immunodetection for Western blotting and protein normalization from Advanced ImmunoChemical.

25 Mar, 2017

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Here we announce a direct MAb 6C5-HRP conjugate in place of secondary antibodies plus a GAPDH loading control for Western blots and protein normalization available online. Click here: GAPDH Western blot Set. GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is one of the key enzymes involved in glycolysis, catalyzing the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate. Besides functioning as a … Read more

Myeloperoxidase (MPO): inflammation marker that can serve as cardiac marker.

16 Feb, 2017

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Here at Advanced ImmunoChemical, Inc., we announce a new generation of anti-MPO monoclonal antibodies suitable for the development of quantitative MPO immunoassay. Sandwich immunoassays utilizing these antibodies demonstrated exceptionable results in precise MPO immunodetection in patient’s blood samples as shown in our AssayNotes: Click here for Myeloperoxidase AssayNotes and product information. MPO causes oxidative modification … Read more

Urine RBP4: best biomarker of impaired renal proximal tubule function and risk stratification of insulin-resistant patients.

24 Jan, 2017

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Urine retinol-binding protein4 (RBP4), a carrier protein for vitamin A in plasma, is arguably the most sensitive biomarker of human proximal renal tubular function known. Advanced ImmunoChemical is pleased to offer anti-human RBP4 monoclonal antibodies, as well as purified endogenous RBP4 for quantitative detection of circulating RBP4. Urine RBP4 AssayNotes and product information. Impaired tubule … Read more

Article about cTnI autoantibodies and what they tell us about circulating troponins- Courtesy of HyTest, Ltd.

20 Jan, 2017

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Research Courtesy of HyTest, Ltd.  The presence of cardiac troponin I autoantibodies in blood has been known for a long time. These autoantibodies bind to the stable part of cTnI and may be found in the blood of both healthy people and people with different diseases. They may interfere with the cTnI tests if the … Read more

Heart-type fatty acid binding protein (H-FABP): a diagnostic marker for early stage AMI and myocardial ischemia, with or without necrosis.

25 Oct, 2016

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Heart-type fatty acid binding protein (H-FABP) is a small (15 kDa) cytoplasmic protein that is abundant in tissues with active fatty acid metabolism, including the heart. Following ischemic injury, H-FABP is quickly released into the circulation via porous endothelial membranes of cardiac myocytes.  Myocardial damage can be evaluated in plasma within 1-3 hours after symptom … Read more

Lipoprotein-associated phospholipase A2 (Lp-PLA2): prognostic biomarker of adverse cardiac-related events.

30 Sep, 2016

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Now available:  Advanced ImmunoChemical offers five In vitro produced lipoprotein-associated phospholipase A2 (Lp-PLA2)-specific murine antibodies and recombinant human Lp-PLA2 protein for high performance quantitative immunoassay measurement of Lp-PLA2 in mass units (ng/ml). Click here:  view Lp-PLA2 product performance information. Four major international societies including the American Heart Association, the European Society of Cardiology, the American College of Cardiology, and the … Read more

Detection of influenza and other acute respiratory viruses: haemagglutinin-specific antibodies and viral antigens for assay development and research.

20 Sep, 2016

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Advanced ImmunoChemical offers 15 antigens of influenza and other acute respiratory diseases, as well as a selection of monoclonal antibodies for the detection of these respiratory illnesses: influenza type A and type B, respiratory syncytial virus, adenovirus, and Newcastle disease. These haemagglutinin-specific antibodies are suitable for the detection of specific strains of influenza through ELISA and Western … Read more

Human BNP and NT-proBNP: biomarkers for diagnosis of heart failure, predictive mortality and cardiovascular risk stratification.

14 Sep, 2016

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Advanced ImmunoChemical offers antigens and corresponding high affinity monoclonal antibodies specific to recombinant human BNP, proBNP, and NT-proBNP for the development of sensitive, reliable immunoassays specific to regions not affected by glycosylation during proBNP processing. Also a New Novel Single Epitope Sandwich (SES) assay for precise quantification of circulating BNP and proBNP in HF patients. … Read more

Recombinant canine N-terminal pro-B-type natriuretic peptide (NT-proBNP) and monoclonal antibodies for the detection of canine cardiomyopathy.

27 Jul, 2016

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Advanced ImmunoChemical offers 11 monoclonal antibodies and the recombinant antigen for the detection of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in canines. These products are sufficient for immunoassay development for the determination of NT-proBNP levels in canine blood. All antibodies offered have shown to identify both the recombinant and native NT-proBNP in canine blood. Click here to … Read more

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