C-reactive protein (CRP) is a major acute phase protein in dogs. Its concentration increases rapidly and significantly during systemic inflammation and subsequently decreases quickly following the elimination of the source of inflammation. Kinetics of canine CRP (cCRP) in an acute phase response are similar to those of human CRP. The synthesis of CRP in hepatocytes is induced by inflammatory cytokines shortly after the inflammatory stimulus. However, whilst CRP plays an important role in innate immune response, its precise function appears to be complex and still somewhat unclear.