Update: December 01, 2021 Anti-SARS-CoV-2 nucleoprotein antibodies Anti-SARS-CoV-2 nucleoprotein antibodies (Cat.# 5-CVnp, MAbs C518, C524, C527, C706, C715) bind to the N-terminal part of the nucleoprotein: N47-A173. Several mutations found in circulating SARS-CoV-2 variants are located outside of this region however. Thus, it is important to test all relevant and concerning mutations regardless of their … Read more
Various biomarkers, especially inflammatory markers like C-reactive protein (CRP), ferritin, fibrinogen, D-dimer and Interleukin 6 (IL-6) are associated with Covid-19 progression. And cytokine-mediated inflammation, also described as cytokine storm, plays an important role in severe cases of COVID-19 and is reported as a major cause of death. IL-6 is produced by the stromal cells and … Read more
New Recommended MAb Pairs D-dimer has been commonly elevated in patients with SARS-CoV-2. It has been shown to correlate with disease severity and to be a reliable prognostic marker for hospitalization and mortality assessment in patients admitted for COVID-19. Elevated levels of D-dimer have been found in the blood of patients with pulmonary embolism (PE) … Read more
Interleukin-6 (IL-6) has been shown to be involved in many physiologic activities, disease initiation and progression and the pleiotropic nature of this cytokine makes it a key player in many physiologic processes (1). Serum IL-6 levels have also upregulated during recent outbreaks of coronavirus and are associated with severity of COVID-19 infection (2). IL-6 could … Read more
NGAL (neutrophil gelatinase-associated lipocalin) is a small glycoprotein found in blood and urine. It is expressed by kidney tubular cells after kidney injury and it has been indicated as a promising biomarker of acute kidney injury. In addition, NGAL concentration is known to increase in severe infections. New product. At Advanced ImmunoChemical, we provide several mouse and … Read more
Advanced ImmunoChemical now has available anti-SARS-CoV-2 nucleoprotein monoclonal antibodies (anti-SC-NP) that are expected to detect both the United Kingdom and South African variants of SARS-CoV-2. The UK variant of SARS-CoV-2 (known as VOC 202012/01, lineage B.1.1.7, or 20B/501Y.V1) has two mutations in the nucleoprotein: D3L and S235F. The epitope specificities of our key anti-SC-NP monoclonal antibodies: … Read more
New. Biomarkers to screen for mysterious heart damage and other health issues befalling some COVID-19 patients. Testing for SARS-CoV-2 is not the only requirement in regards to managing COVID-19. Screening and monitoring for the various health issues that may arise as part of COVID-19 disease management are also needed. You can find the following biomarkers in … Read more
Monoclonal Antibodies for Development of COVID-19 Serology Assays To detect and measure the levels of SARS-CoV-2 antibodies as a result of exposure to COVID-19 will provide valuable information on the development of individual immunity. COVID-19 specific IgM antibodies can be detected after 3-5 days from onset of the disease. IgG antibodies appear later, however, their … Read more
Canine C-reactive protein (cCRP) is a major acute phase protein in dogs. Its concentration increases rapidly and significantly during systemic inflammation and subsequently decreases quickly following the elimination of the source of inflammation. Several studies support the view that cCRP is a valuable diagnostic marker for the detection of the acute phase response in dogs. Its … Read more
New D-dimer monoclonal antibodies (DD189 and DD255) allow for development of an improved immunoassay to detect D-dimer. Elevated levels of D-dimer are found in the blood of patients with pulmonary embolism, deep vein thrombosis and atherosclerosis. D-dimer diagnostic tests are widely used to exclude the diagnosis of deep vein thrombosis. In addition, increased amount of D-dimer … Read more
Open full PDF Procalcitonin AssayNotes Procalcitonin (PCT) is a small protein (~13 kDa) that is synthesized by the C-cells of the thyroid glands. It is considered to be the main marker of disorders that are accompanied by systemic inflammation and sepsis. PCT is encoded by the CALC-1 gene and it is the precursor of the … Read more
Canine parvovirus, type 2 (CPV-2) causes a severe and highly contagious disease in dogs. A common manifestation of parvovirus infection is hemorrhagic enteritis. The disease can be prevented by vaccination and the CPV-2 vaccine is recommended as a core vaccine that should be given to all dogs. Advanced ImmunoChemical now offers recombinant CPV-2 capsid protein … Read more
Tumor biomarkers play a crucial role in monitoring of response to therapy and in post-treatment surveillance of various gastrointestinal and gynecological malignancies. While the clinical value of FDA-approved tumor markers such as CEA, CA19-9 and CA125 has been established, adequate data to support FDA approval of CA72-4 as a potential biomarker are lacking and its … Read more
Coming soon: Anti-Müllerian Hormone MAbs and Recombinant Protein. Anti-Müllerian hormone (AMH) is increasingly utilized as a biomarker of women’s reproductive health. AMH levels correlate to the size of the follicle pool. In addition, it can be used to assess the response of in vitro fertility treatment. Anti-Mullerian Hormone (AMH) is expressed by granulosa cells. Production declines when follicles … Read more
Open full PDF High-sensitivity CRP AssayNotes. C-reactive protein (CRP) was originally discovered by Tillett and Francis in 1930 as a substance in the serum of patients with acute inflammation that reacted with the C polysaccharide of pneumococcus. CRP is a 224 residue protein with a monomer molecular mass about 25 kDa and pI 6.4. Monomers are … Read more
Open PDF Human Papillomavirus (HPV) AssayNotes Human papillomavirus (HPV) belongs to Papillomaviruses, a diverse group of DNA-based viruses that infect the skin and mucous membranes of humans and a variety of animals. Over 100 different human papillomavirus (HPV) types have been identified on the basis of difference in the virus genome nucleotide sequences (e.g. type … Read more
Properties Description: SmarTaq DNA Polymerase is complex mixture of a thermostable 94 kDa BioTaq DNA Polymerase purified from E. coli PVG-AI recombinant strain expressing Thermus aquaticus polymerase gene and specific monoclonal antibodies. SmarTaq from Advanced ImmunoChemical, Inc. is inactive under conditions of amplification reaction preparation. It provides improved specificity when compared to standard DNA polymerases. SmarTaq can eliminate amplification artifacts such … Read more
Osteocalcin AssayNotes: Open full PDF Osteocalcin AssayNotes Osteocalcin (OC), which is also known as bone Glaprotein (BGP), is a vitamin K-dependent bone matrix peptide of 49 amino acid residues. The concentration of OC in serum is considered to be an index of bone formation and numerous immunoassays for the measurement of OC have been developed in … Read more
Advanced ImmunoChemical offers five In vitro produced lipoprotein-associated phospholipase A2 (Lp-PLA2)-specific murine antibodies and recombinant human Lp-PLA2 protein for high performance quantitative immunoassay measurement of Lp-PLA2 in mass units (ng/ml). Click here: view Lp-PLA2 product performance information. Four major international societies including the American Heart Association, the European Society of Cardiology, the American College of Cardiology, and the American Society of Endocrinology … Read more
Cystatin C AssayNotes Open full Cystatin C AssayNotes pdf. Cystatin C is a low molecular weight (13.4 kDa) cytoplasmic protein functioning as an inhibitor of various cystein proteases in the bloodstream. It inhibits both endogenous proteases, such as lysosomal cathepsines, and proteases of parasites and microbes. Cystatin C binds to the target molecule in µM … Read more