Category: Assay Notes

Canine thyroid stimulating hormone (TSH, thyrotropin): biomarker to reliably evaluate thyroid function

5 Dec, 2017

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Canine thyroid stimulating hormone (TSH, thyrotropin): biomarker to reliably evaluate thyroid function

New Products: Canine TSH MAbs and Recombinant Antigen Hypothyroidsim is one of the most frequent canine endocrine disorders. The diagnosis of hypothyroidism is based on the presence of clinical signs, thyroid function test results and response to the thyroid hormone replacement therapy. A low circulating total T4 concentration suggests hypothyroidism. However, in order to reliably evaluate … Read more

Human proBNP, BNP and NT-proBNP: diagnostic and prognostic biomarker of heart failure.

28 Nov, 2017

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Human proBNP, BNP and NT-proBNP: diagnostic and prognostic biomarker of heart failure.

Brain natriuretic peptide (BNP) and the N-terminal part of the BNP precursor proBNP (NT-proBNP) are established diagnostic and prognostic biomarkers of heart failure (HF). HF is a severe clinical and public health problem that is characterized by an increasing prevalence and economic cost. Chronic heart disease, hypertension and diabetes are among the known risk factors … Read more

Kidney Injury Molecule-1 (KIM-1): early diagnostic urinary marker

7 Jun, 2017

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Kidney Injury Molecule-1 (KIM-1): early diagnostic urinary marker

It is well known that kidney injuries can tend to accom­pany many severe illness­es such as cardiac diseas­es, trauma and sepsis, and is an increasingly common and devastating compli­cation in hospitalized pa­tients. Despite improve­ments in health outcomes in many areas during recent years, mortality and morbidity rates asso­ciated with acute kidney injury (AKI) remain very … Read more

Canine C-reactive Protein (cCRP): biomarker for systemic inflammation and tissue damage, particularly in neoplastic and immune-mediated diseases.

10 May, 2017

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Canine C-reactive Protein (cCRP): biomarker for systemic inflammation and tissue damage, particularly in neoplastic and immune-mediated diseases.

Acute phase proteins (APPs) constitute a group of proteins whose blood concentration changes rapidly in response to stressors such as infection and tissue damage. C-reactive protein (CRP) is a representative APP with synthesis in hepatocytes greatly increasing during systemic inflammation and in various disorders including viral and bacterial infections, sepsis and surgical trauma (1-3). Advanced … Read more

Gangliosides: distribution in brain and nervous tissues indicates important roles with cell external ligands and membrane components.

2 May, 2017

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Gangliosides: distribution in brain and nervous tissues indicates important roles with cell external ligands and membrane components.

Gangliosides are a large group of sialylated glycosphingolipids that are widely expressed in mammalian tissues and are particularly abundant in brain and nervous tissues. The differential distribution of gangliosides in various tissues is a strong indication they play important roles in specific functions in different tissues. Gangliosides as a full product line are now available … Read more

Detecting pathogens and toxins transmitted to humans and vertebrates via contaminated food and water: Caliciviridae (norovirus) et al.

6 Apr, 2017

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Detecting pathogens and toxins transmitted to humans and vertebrates via contaminated food and water: Caliciviridae (norovirus) et al.

Advanced ImmunoChemical, Inc. offers 5 different high quality monoclonal antibodies (MAbs) for the detection of caliciviruses. The antibodies were developed using feline calicivirus (FCV) and rabbit hemorrhagic disease virus (RHDV) as immunogens in order to obtain antibodies that would detect the most common epitopes of different caliciviruses. All MAbs detect human norovirus, feline calicivirus and … Read more

Myeloperoxidase (MPO): inflammation marker that can serve as cardiac marker.

16 Feb, 2017

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Myeloperoxidase (MPO): inflammation marker that can serve as cardiac marker.

Here at Advanced ImmunoChemical, Inc., we announce a new generation of anti-MPO monoclonal antibodies suitable for the development of quantitative MPO immunoassay. Sandwich immunoassays utilizing these antibodies demonstrated exceptionable results in precise MPO immunodetection in patient’s blood samples as shown in our AssayNotes: Click here for Myeloperoxidase AssayNotes and product information. MPO causes oxidative modification … Read more

Urine RBP4: best biomarker of impaired renal proximal tubule function and risk stratification of insulin-resistant patients.

24 Jan, 2017

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Urine RBP4: best biomarker of impaired renal proximal tubule function and risk stratification of insulin-resistant patients.

Urine retinol-binding protein4 (RBP4), a carrier protein for vitamin A in plasma, is arguably the most sensitive biomarker of human proximal renal tubular function known. Advanced ImmunoChemical is pleased to offer anti-human RBP4 monoclonal antibodies, as well as purified endogenous RBP4 for quantitative detection of circulating RBP4. Urine RBP4 AssayNotes and product information. Impaired tubule … Read more

Heart-type fatty acid binding protein (H-FABP): a diagnostic marker for early stage AMI and myocardial ischemia, with or without necrosis.

25 Oct, 2016

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Heart-type fatty acid binding protein (H-FABP): a diagnostic marker for early stage AMI and myocardial ischemia, with or without necrosis.

Heart-type fatty acid binding protein (H-FABP) is a small (15 kDa) cytoplasmic protein that is abundant in tissues with active fatty acid metabolism, including the heart. Following ischemic injury, H-FABP is quickly released into the circulation via porous endothelial membranes of cardiac myocytes.  Myocardial damage can be evaluated in plasma within 1-3 hours after symptom … Read more

Lipoprotein-associated phospholipase A2 (Lp-PLA2): prognostic biomarker of adverse cardiac-related events.

30 Sep, 2016

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Lipoprotein-associated phospholipase A2 (Lp-PLA2): prognostic biomarker of adverse cardiac-related events.

Now available:  Advanced ImmunoChemical offers five In vitro produced lipoprotein-associated phospholipase A2 (Lp-PLA2)-specific murine antibodies and recombinant human Lp-PLA2 protein for high performance quantitative immunoassay measurement of Lp-PLA2 in mass units (ng/ml). Click here:  view Lp-PLA2 product performance information. Four major international societies including the American Heart Association, the European Society of Cardiology, the American College of Cardiology, and the … Read more

Detection of influenza and other acute respiratory viruses: haemagglutinin-specific antibodies and viral antigens for assay development and research.

20 Sep, 2016

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Detection of influenza and other acute respiratory viruses: haemagglutinin-specific antibodies and viral antigens for assay development and research.

Advanced ImmunoChemical offers 15 antigens of influenza and other acute respiratory diseases, as well as a selection of monoclonal antibodies for the detection of these respiratory illnesses: influenza type A and type B, respiratory syncytial virus, adenovirus, and Newcastle disease. These haemagglutinin-specific antibodies are suitable for the detection of specific strains of influenza through ELISA and Western … Read more

Human BNP and NT-proBNP: biomarkers for diagnosis of heart failure, predictive mortality and cardiovascular risk stratification.

14 Sep, 2016

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Human BNP and NT-proBNP: biomarkers for diagnosis of heart failure, predictive mortality and cardiovascular risk stratification.

Advanced ImmunoChemical offers antigens and corresponding high affinity monoclonal antibodies specific to recombinant human BNP, proBNP, and NT-proBNP for the development of sensitive, reliable immunoassays specific to regions not affected by glycosylation during proBNP processing. Also a New Novel Single Epitope Sandwich (SES) assay for precise quantification of circulating BNP and proBNP in HF patients. … Read more

Recombinant canine N-terminal pro-B-type natriuretic peptide (NT-proBNP) and monoclonal antibodies for the detection of canine cardiomyopathy.

27 Jul, 2016

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Recombinant canine N-terminal pro-B-type natriuretic peptide (NT-proBNP) and monoclonal antibodies for the detection of canine cardiomyopathy.

Advanced ImmunoChemical offers 11 monoclonal antibodies and the recombinant antigen for the detection of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in canines. These products are sufficient for immunoassay development for the determination of NT-proBNP levels in canine blood. All antibodies offered have shown to identify both the recombinant and native NT-proBNP in canine blood. Click here to … Read more

Human Serum Amyloid A (SAA): biomarker of inflammatory response from tissue injury or trauma. Precursor to AA (inflammatory) amyloidosis.

26 Jul, 2016

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Human Serum Amyloid A (SAA): biomarker of inflammatory response from tissue injury or trauma. Precursor to AA (inflammatory) amyloidosis.

Human serum amyloid A (SAA) is an acute phase protein that acts as a biomarker of inflammation caused by tissue injury or other traumas. The typical concentration of SAA in human blood in about 1-10 ug/ml, but during inflammation, this concentration rises to levels above 1 mg/ml (1). The primary function of SAA is to recycle and reuse cholesterol … Read more

Veterinary Diagnostics: antibodies and antigens for immunoassay development for several animal diseases from Advanced ImmunoChemical.

25 Jul, 2016

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Veterinary Diagnostics: antibodies and antigens for immunoassay development for several animal diseases from Advanced ImmunoChemical.

We offer monoclonal antibodies and recombinant antigens for diagnostic immunoassays for several animal diseases, including cardiovascular disease, inflammation, infectious and renal diseases. CANINE NEW! Canine C-reactive Protein (cCRP), Antibodies — (Cat #2-CRP-c) & Recombinant Canine C-reactive Protein (cCRP) — (Cat #7-CRP-c)      NEW! Canine Serum Amyloid A (SAA) — (Cat #2-SAA-a) & Recombinant Canine Serum Amyloid A … Read more

GAPDH antibodies and recombinant antigens: an investigative tool plus loading control in clinical research.

19 Jul, 2016

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GAPDH antibodies and recombinant antigens: an investigative tool plus loading control in clinical research.

 Advanced ImmunoChemical offers 5 monoclonal antibodies, in addition to the recombinant human and recombinant rabbit antigens, for the detection of glyceraldehyde-3-phosphate dehydrogenase, an enzyme known for its catalyzing role in glycolysis. These antibodies and antigens are sufficient for immunodetection of GAPDH by Western blotting, sandwich immunoassays, and other immunocytochemical processes. Click here to view GAPDH Product … Read more

A Diagnostic Marker for Veterinary Inflammation: Feline, Canine, and Equine Serum Amyloid A

28 Jun, 2016

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A Diagnostic Marker for Veterinary Inflammation: Feline, Canine, and Equine Serum Amyloid A

Advanced ImmunoChemical now offers 8 monoclonal antibodies (MAbs) for the detection of canine and equine serum amyloid A (SAA), with 6 of the antibodies also detecting feline SAA.  For calibration, we offer native purified recombinant equine, canine, and feline SAA proteins. The MAbs are sufficient for measurement in plasma with all recognizing equine and canine SAA, and 6 recognizing feline SAA in both … Read more

Adiponectin: diagnostic marker of type 2 diabetes and cardiovascular diseases.

9 Jun, 2016

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Adiponectin: diagnostic marker of type 2 diabetes and cardiovascular diseases.

Advanced ImmunoChemical offers monoclonal antibody pairs to different oligomeric forms of human adiponectin.  In addition, for calibration and assay development, we offer native purified human adiponectin for reliable, adiponectin-specific assays that do not cross-react with the closest structural homolog, human C1q. Click here to view Adiponectin Product Performance Information: In blood, adiponectin is found as trimers (LMW), hexamers (MMW) and … Read more

Biomarkers of Diabetes: antigens and antibodies for the detection of HbA1c, C-peptide, and insulin.

5 May, 2016

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Biomarkers of Diabetes: antigens and antibodies for the detection of HbA1c, C-peptide, and insulin.

Advanced ImmunoChemical offers antibodies and antigens for the detection of various diabetes markers such as HbA1c, C-peptide and insulin. HbA1c A number of studies have shown that glycated hemoglobin (HbA1c) concentration provides a better estimate of average hyperglycemia than routine blood glucose concentration.  HbA1c measurement in diagnosis of type 2 diabetes has been recommended by American … Read more

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