S-100 protein, ββ homodimer and αβ heterodimer, bovine

Catalog Number: 8-S100ab-b

From: $613.00

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General Category:

    Antigens » Veterinary » Bovine
    Antigens » Neuroscience
    Antigens » Cardiac Markers » Other cardiac markers

Disease Category:

    Neuroscience » Antigens
    Veterinary » Antigens » Bovine
    Cardiac Markers » Antigens » Other cardiac markers
Bovine brain tissue.
S-100 protein derived from brain tissue is an acidic calcium-binding protein with molecular weight of about 21kDa. In human brain tissue S-100 protein is mainly presented by two isoforms – ββ
homodimer (S-100b) and αβ heterodimer (S-100a). Because of its predominant location in astroglial cells S-100 protein can be used as a sensitive and reliable marker for central nervous system injury. Structural damage of glial cells causes leakage of S-100 protein into the extracellular matrix and into cerebrospinal fluid, further releasing into the bloodstream. Measurements of S-100 protein in patient serum samples are useful in monitoring of traumatic brain injury, ischemic brain damage after circulatory arrests, in diagnosis and prognosis of clinical outcome in acute stroke. S-100 protein is suitable for use as a standard in immunoassay, as an immunogen for antiserum production and tracer for iodination.
Purity > 95 %. After native gel electrohoresis by Ornstein-Davis S-100 protein is presented by two bands corresponding to αβ- and ββ-forms.
S-100 protein concentration was determined by Lowry method using BSA as a standard.
Lyophilized from 5 mM Tris-HCl, pH 7.5 with 5 mM 2-mercaptoethanol and 5 mM EDTA.
Product is recommended to reconstitute with 5 mM 2-mercaptoethanol.
Storage Conditions:
-20 °C (between -15 and -30 °C allowed)
Other information:
Avoid repeated freezing and thawing.
It is recommended to aliquot the product after reconstitution. This product is available only in research amounts.
Material safety note:
This product is sold for research use only. Standard Laboratory Practices should be followed when handling this material.
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