Recent Citations

Citations: 2010 – 2016

EZH2 inhibition blocks multiple myeloma cell growth through upregulation of epithelial tumor suppressor genes

H Hernando, KA Gelato, R Lesche, G Beckmann… – Molecular cancer …, 2015
Abstract Multiple myeloma is a plasma cell malignancy characterized by marked
heterogeneous genomic instability including frequent genetic alterations in epigenetic
enzymes. In particular, the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2

HSP20 Peptide Decreases Human Airway Constriction Downstream of β2 Adrenergic Receptor

A Banathy, J Cheung-Flynn, K Goleniewska, KL Boyd… – American journal of …, 2016
Severe bronchospasm refractory to β-agonists is a challenging aspect of asthma therapy
and novel therapeutics are needed. β-agonist-induced airway smooth muscle (ASM)
relaxation is associated with increases in the phosphorylation of the small heat-shock

Epidermal Growth Factor Receptor Signaling to the Mitogen Activated Protein Kinase Pathway Bypasses Ras in Pancreatic Cancer Cells

S Lee, EL Heinrich, J Lu, W Lee, AH Choi, C Luu… – Pancreas, 2016
Objective: Epidermal growth factor (EGF) receptor (EGFR/HER1) is overexpressed in human
pancreatic cancers. However, anti-EGFR therapy does not exhibit significant therapeutic
activity with oncogenic K-ras mutation. We sought to assess the signaling relationship

Role of mTOR Downstream Effector Signaling Molecules in Francisella Tularensis Internalization by Murine Macrophages

MW Edwards, JA Aultman, G Harber, JM Bhatt, E Sztul… – PloS one, 2013
Abstract Francisella tularensis is an infectious, gram-negative, intracellular microorganism,
and the cause of tularemia. Invasion of host cells by intracellular pathogens like Francisella
is initiated by their interaction with different host cell membrane receptors and the rapid

Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2, 3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, …

SY Min, M Yan, SB Kim, S Ravikumar, SR Kwon… – Journal of Inflammation, 2015
Background The activity of one of the major catechins in Green Tea, the polyphenol (−)-
epigallocatechin-3-gallate (EGCG), has been shown to have a variety of health benefits.
Recent studies suggest that EGCG can modulate both the innate and adaptive arms of the

Seroprevalences of Toxoplasma gondii and Neospora caninum in Pet Rabbits in Japan

D Salman, E Oohashi, AEA Mohamed… – Journal of Veterinary …, 2014
The potential contamination of Toxoplasma gondii and Neospora caninum oocysts in the
human environment is a concern from the public health viewpoint. However, estimation of
their seroprevalences in humans cannot be performed in a manner that distinguishes

Overproduction of Toxoplasma gondii cyclophilin-18 regulates host cell migration and enhances parasite dissemination in a CCR5-independent manner

HM Ibrahim, M Nishimura, S Tanaka, W Awadin… – BMC microbiology, 2014
Background Toxoplasma gondii hijacks host cells to allow it to disseminate throughout a
host animal; however, the migratory machinery involved in this process has not been well
characterized. We examined the functional role of T. gondii cyclophilin 18 (TgCyp18) in

Role of Cyclic Nucleotide-Dependent Actin Cytoskeletal Dynamics:[Ca 2+] i and Force Suppression in Forskolin-Pretreated Porcine Coronary Arteries

KM Hocking, FJ Baudenbacher, G Putumbaka… – PloS one, 2013
Abstract Initiation of force generation during vascular smooth muscle contraction involves a
rise in intracellular calcium ([Ca 2+] i) and phosphorylation of myosin light chains (MLC).
However, reversal of these two processes alone does not account for the force inhibition

5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis

FG Kapp, A Sommer, T Kiefer, G Dölken, B Haendler – Cancer cell international, 2012
Background Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies
and has a high mortality rate due to late detection and lack of efficient treatments. Identifying
novel drug targets for this indication may open the way for new treatment strategies.

Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein

R Terrasse, P Tacnet-Delorme, C Moriscot, J Pérard… – Journal of Biological …, 2012
↵3 To whom correspondence may be addressed: Pneumococcus Group (PG), Inst. de Biologie
Structurale Jean-Pierre Ebel, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France. Tel.:
33-4-38-78-56-34; Fax: 33-4-38-78-54-94; E-mail: anne-marie.di-guilmi{at}

Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver

C Moffat, L Bhatia, T Nguyen, P Lynch, M Wang… – Journal of lipid research, 2014
Abstract Acyl-CoA thioesterase (Acot) 2 localizes to the mitochondrial matrix and hydrolyses
long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxidative
tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role

Modulation of the Sensitivity of Jurkat T-Cells to Inhibition of Protein Synthesis by Tumor Necrosis Factor α-Related Apoptosis-Inducing Ligand

A Elia, IR Powley, M MacFarlane, MJ Clemens – Journal of Interferon & Cytokine …, 2014
Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is a potent inducer of
apoptosis in Jurkat T lymphoma cells. One of the characteristics of the phase preceding
overt apoptosis is the marked downregulation of protein synthesis. We have investigated

Mechanisms of interferon‐beta‐induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity‐related GTPase …

ME Mahmoud, F Ui, D Salman, M Nishimura… – Cellular microbiology, 2015
Summary The apical complex of Toxoplasma gondii enables it to invade virtually all
nucleated cells in warm-blooded animals, including humans, making it a parasite of global
importance. Anti-T. gondii cellular defence mechanisms depend largely on interferon (IFN)

LncRNA uc. 48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia

S Wang, H Xu, L Zou, J Xie, H Wu, B Wu, Z Yi, Q Lv… – Purinergic signalling, 2015
Abstract Some long non-coding RNAs (lncRNAs) participate in physiological processes that
maintain cellular and tissue homeostasis, and thus, the dysregulated expression of lncRNAs
is involved in the onset and progression of many pathological conditions. Research has

Cyclin-Cyclin-dependent Kinase Regulatory Response Is Linked to Substrate Recognition

ME Cuomo, GM Platt, LH Pearl, S Mittnacht – Journal of Biological Chemistry, 2011
Abstract Cyclin/cyclin-dependent kinase (CDK) complexes are critical regulators of cellular
proliferation. A complex network of regulatory mechanisms has evolved to control their
activity, including activating and inactivating phosphorylation of the catalytic CDK subunit

Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome

M Jiang, RT Ash, SA Baker, B Suter, A Ferguson… – The Journal of …, 2013
Abstract MECP2 duplication syndrome is a childhood neurological disorder characterized by
intellectual disability, autism, motor abnormalities, and epilepsy. The disorder is caused by
duplications spanning the gene encoding methyl-CpG-binding protein-2 (MeCP2), a

Endorepellin, perlecan angiostatic module, interacts with both the [alpha] 2 [beta] 1 integrin and VEGFreceptor 2: A dual receptor antagonism

A Goyal, N Pal, M Concannon, M Paul, M Doran… – Journal of Biological …, 2011
Abstract Endorepellin, the C-terminal module of perlecan, negatively regulates
angiogenesis counter to its proangiogenic parental molecule. Endorepellin binds α2β1i
integrin on endothelial cells and triggers a signaling cascade that leads to disruption of

Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon

MD Faye, TE Graber, P Liu, N Thakor, SD Baird… – Molecular and cellular …, 2013
ABSTRACT The vast majority of cellular mRNAs initiate their translations through a well-
defined mechanism of ribosome recruitment that occurs at the 5′-terminal 7-
methylguanosine cap with the help of several canonical protein factors. A subset of

Adaptations of the Endothelin System After Exercise Training in a Porcine Model of Ischemic Heart Disease

JC Robles, CL Heaps – Microcirculation, 2015
Objective To the test the hypothesis that exercise training would increase endothelin-
mediated vasoconstriction in collateral-dependent arteries via enhanced contribution of ET
A. Methods An ameroid constrictor was surgically placed around the proximal LCX artery

Converging pathways involving microRNA-206 and the RNA-binding protein KSRP control post-transcriptionally utrophin A expression in skeletal muscle

A Amirouche, H Tadesse, P Miura, G Bélanger… – Nucleic acids research, 2014
Abstract Several reports have previously highlighted the potential role of miR-206 in the post-
transcriptional downregulation of utrophin A in cultured cells. Along those lines, we recently
identified K-homology splicing regulator protein (KSRP) as an important negative

Method of determining a concentration of analytes of interest in a sample

F Mallwitz, U Dahmen-Levison, D Levison, S Levison – US Patent 8,173,379, 2012
A method of determining a concentration of analytes of interest in a sample reaction mixture
is disclosed. The method can include measuring intensities of the polarized fluorescence of
at least one comparative reaction mixture containing different, known amounts of the

RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins

M Arora, CZ Packard, T Banerjee, JD Parvin – Nucleic acids research, 2015
Abstract During mitosis the chromatin undergoes dramatic architectural changes with the
halting of the transcriptional processes and evacuation of nearly all transcription associated
machinery from genes and promoters. Molecular bookmarking of genes during mitosis is a

Preclinical evaluation of multistep targeting of diasialoganglioside GD2 using an IgG-scFv bispecific antibody with high affinity for GD2 and DOTA metal complex

SM Cheal, H Xu, H Guo, PB Zanzonico, SM Larson… – Molecular cancer …, 2014
Abstract Bispecific antibodies (BsAb) have proven to be useful targeting vectors for
pretargeted radioimmunotherapy (PRIT). We sought to overcome key PRIT limitations such
as high renal radiation exposure and immunogenicity (eg, of streptavidin–antibody fusions

Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel …

SA Cross, DR Cook, AWS Chi, PJ Vance, LL Kolson… – The Journal of Immunology, 2011
Abstract Despite antiretroviral therapy (ART), HIV infection promotes cognitive dysfunction
and neurodegeneration through persistent inflammation and neurotoxin release from
infected and/or activated macrophages/microglia. Furthermore, inflammation and immune

Olive oil compounds inhibit the paracrine regulation of TNF-α-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression

S Lamy, AB Saad, A Zgheib, B Annabi – The Journal of nutritional biochemistry, 2016
Abstract The established causal relationship between the chronic inflammatory
microenvironment, tumor development and cancer recurrence has provided leads for
developing novel preventive strategies. Accumulating experimental, clinical and

Pre-clinical evaluation of a replication-competent recombinant adenovirus serotype 4 vaccine expressing influenza H5 hemagglutinin

J Alexander, S Ward, J Mendy, DJ Manayani… – PLoS One, 2012
Background Influenza virus remains a significant health and social concern in part because
of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1
vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector,

Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth

DA Ucar, EV Kurenova, TJ Garrett, WG Cance… – Carcinogenesis, 2011
Abstract Previously, we have shown that focal adhesion kinase (FAK) and insulin-like growth
factor receptor-1 (IGF-1R) directly interact with each other and, thereby, activate crucial
signaling pathways that benefit cancer cells. Inhibition of FAK and IGF-1R function have

Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein

D Alvira, R Naughton, L Bhatt, S Tedesco, WD Landry… – Journal of Biological …, 2011
Abstract Chronic myelogenous leukemia (CML) is a myeloproliferative disorder
characterized at the molecular level by the expression of Bcr-Abl, a chimeric protein with
deregulated tyrosine kinase activity. The protein-tyrosine phosphatase 1B (PTP1B) is up-

Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions

PX Lim, DR Patel, KE Poisson, M Basuita, C Tsai… – Journal of Biological …, 2015
↵1 To whom correspondence should be addressed: Dept. of Biomedical Sciences, Cornell
University, Tower Rd., Ithaca, NY 14853-6401. Tel.: 607-253-4443; Fax: 607-253-4212;
E-mail: rsw26{at} Background: The 9-1-1 complex mediates checkpoint

Transforming growth factor b1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer- …

X LiuÃ, YS Piao, JT Arnold – Carcinogenesis, 2011
Transforming growth factor b1 (TGF-b1) increases dehydroepiandrosterone (DHEA)
metabolism to androgens and prostatespecific antigen (PSA) in a prostate tissue model
where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC)

Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer’s disease

DE Hurtado, L Molina-Porcel, JC Carroll… – The Journal of …, 2012
Abstract Glycogen synthase kinase-3 (GSK-3) is linked to the pathogenesis of Alzheimer’s
disease (AD), senile plaques (SPs), and neurofibrillary tangles (NFTs), but the specific
contributions of each of the GSK-3 α and β isoforms to mechanisms of AD have not been

Androgen‐induced PSA expression requires not only activation of AR but also endogenous IGF‐I or IGF‐I/PI3K/Akt signaling in human prostate cancer epithelial cells

X Liu, RY Choi, SM Jawad, JT Arnold – The Prostate, 2011
BACKGROUND Prostate cancer (PrCa) risk is positively associated with levels of insulin-like
growth factor I (IGF-I) and prostate specific antigen (PSA), both androgen receptor (AR)
signaling target genes in PrCa cells. Although activated AR is required for androgen-

Calcium sensitization of cardiac myofilament proteins contributes to exercise training-enhanced myocardial function in a porcine model of chronic occlusion

M Muthuchamy, CL Heaps – American Journal of Physiology-Heart and …, 2011
Abstract Exercise training has been shown to improve cardiac dysfunction both in patients
and animal models of coronary artery disease; however, the underlying cellular and
molecular mechanisms have not been completely understood. We hypothesized that

Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expression

L Yin, P Rao, P Elson, J Wang, M Ittmann… – PLoS One, 2011
Abstract Prostate specific membrane antigen (PSMA) is overexpressed in prostatic
adenocarcinoma (CaP), and its expression is negatively regulated by androgen stimulation.
However, it is still unclear which factors are involved in this downregulation. TMPRSS2-

Method and compositions for immunization with the Pseudomonas V antigen My Citations

DW Frank, J Wiener-Kronish, TL Yahr, T Sawa, RB Fritz – US Patent 8,101,347, 2012
1. An isolated monoclonal antibody that specifically binds to Pseudomonas aeruginosa PcrV
antigen, wherein the antibody comprises a heavy chain (SEQ. ID NO: 2) and a light chain
(SEQ. ID NO: 4) wherein the antibody or a fragment thereof specifically binds to an

Activation of ExoU phospholipase activity requires specific C-terminal regions My Citations

KM Schmalzer, MA Benson, DW Frank – Journal of bacteriology, 2010
ABSTRACT Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that
utilizes a type III secretion system to subvert host innate immunity. Of the 4 known effector
proteins injected into eukaryotic cells, ExoS and ExoU are cytotoxic. The cytotoxic

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