Recent Citations

Abstract Exercise training is a well-known coadjuvant in heart failure treatment; however, the
molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary
cause, heart failure is often preceded by two distinct phenomena: mitochondria …

Abstract Endorepellin, the C-terminal module of perlecan, negatively regulates
angiogenesis counter to its proangiogenic parental molecule. Endorepellin (the C-terminal
domain V of perlecan) binds the α2β1 integrin on endothelial cells and triggers a signaling …

The ovarian steroid hormone progesterone is essential for normal mammary gland
physiology but may also play a role in breast cancer. Highly potent and selective
antiprogestins may therefore represent a new treatment option for this disease. Here we …

Abstract Preventing losses in vaccine potency due to accidental freezing has recently
become a topic of interest for improving vaccines. All vaccines with aluminum-containing
adjuvants are susceptible to such potency losses. Recent studies have described …

Abstract Regulator of calmodulin (CaM) signaling (RCS), when phosphorylated by protein
kinase A (PKA) on Ser55, binds to CaM and inhibits CaM-dependent signaling. RCS
expression is high in the dorsal striatum, nucleus accumbens and amygdala, suggesting …

RATIONALE: Quantitation and determination of antigen specificity of systemic and mucosal
immune responses to influenza vaccination is beneficial for future vaccine development.
Previous methods to acquire this information were costly, time consuming and sample …

ABSTRACT La Crosse virus (LACV) is a leading cause of pediatric encephalitis and aseptic
meningitis in the midwestern and southern United States, where it is considered an
emerging human pathogen. No specific therapies or vaccines are available for LACV or …

Background Interleukin-27 signaling is mediated by the JAK-STAT pathway via activation of
STAT1 and STAT3, which have tumor suppressive and oncogenic activities, respectively.
Epithelial–mesenchymal transition (EMT) and angiogenesis are key processes in …

Toxoplasma gondii is an intracellular protozoan parasite, which relies on a specialized
compartment, the parasitophorous vacuole (PV), to survive within host cells. Dense granules
within the parasite release a large variety of proteins to maintain the integrity of the …

Aims Reentry accounts for most life-threatening arrhythmias, complicating myocardial
infarction, and therapies that consistently prevent reentry from occurring are lacking. In this
study, we compare antiarrhythmic effects of gene transfer of green fluorescent protein ( …

Increasing connexin43 (Cx43) gap junctional conductance as a means to improve cardiac
conduction has been proposed as a novel antiarrhythmic modality. Yet, transmission of
molecules via gap junctions may be associated with increased infarct size. To determine …

Abstract Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone
(DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue
model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover ( …

Abstract Carboxyl-terminal fragments (CTFs) of TDP-43 aggregate to form the diagnostic
signature inclusions of frontotemporal lobar degeneration and amyotrophic lateral sclerosis,
but the biological significance of these CTFs and how they are generated remain …

Abstract EFhd2 is a conserved calcium-binding protein, abundant within the central nervous
system. Previous studies identified EFhd2 associated with pathological forms of tau proteins
in the tauopathy mouse model JNPL3, which expresses the human tau P301L mutant. …

Abstract The occurrence of a functional relationship between the release of
metalloproteinases (MMPs) and the expression of cyclooxygenase (COX)-2, two inducible
pro-inflammatory biomarkers with important pro-angiogenic effects, has recently been …

METHODS Clinical data and patient demographics. The University and Medical Center
Institutional Review Board approved all aspects of patient recruitment and informed consent
for this study. Cohorts evaluated were diabetic and nondiabetic patients at the East …

Abstract Sagopilone, an optimized fully synthetic epothilone, is a microtubule-stabilizing
compound that has shown high in vitro and in vivo activity against a broad range of human
tumor models. We analyzed the differential mechanism of action of sagopilone in non- …

Methods Here we characterized cardiac ALDH2 activity and expression, lipid peroxidation, 4-
hydroxy-2-nonenal (4-HNE) adduct formation, glutathione pool and mitochondrial energy
metabolism and H 2 O 2 release during the 4 weeks after permanent left anterior …

Objective Current treatment options for lupus are far from optimal. Previously, we reported
that phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin, MEK-1/ERK-1, 2,
p38, STAT-3, STAT-5, NF-κB, multiple Bcl-2 family members, and various cell cycle …

Abstract Current treatments for major depressive disorder (MDD) have a time lag and are
ineffective for a large number of patients. Development of novel pharmacological therapies
requires a comprehensive understanding of the molecular events that contribute to MDD …

Background The cyclooxygenase 2 (COX-2) pathway has been implicated in the molecular
pathogenesis of many malignancies, including lung cancer. Apricoxib, a selective COX-2
inhibitor, has been described to inhibit epithelial-mesenchymal transition (EMT) in human …

Background Peritoneal dissemination of cancer is a terminal condition with limited
therapeutic options. Because the peritoneal cavity is a single enclosed space, regional
treatment approaches for isolated peritoneal cancrinomatosis are appealing. There is a …

Aims Acute myocardial ischaemia induces a decrease in resting membrane potential [which
leads to reduction of action potential (AP) V max] and intracellular acidification (which closes
gap junctions). Both contribute to conduction slowing. We hypothesized that ventricular …

Abstract Inhibition of soluble matrix metalloproteinase (MMP) activity is among the non-
antibiotic cellular effects exerted by the anti-inflammatory tetracycline derivative minocycline.
The impact of minocycline on the signal transduction functions of membrane-bound MMPs …

The identity of biochemical players which underpin the commitment of CD34+ hematopoietic
stem cells to immunogenic or tolerogenic dendritic cells is largely unknown. To explore this
issue, we employed a previously established cell-based system amenable to shift …

Abstract: Purpose: The EGFR tyrosine kinase inhibitors (TKIs) demonstrate efficacy in
NSCLC patients whose tumors harbor activating EGFR mutations. However, patients who
initially respond to EGFR TKI treatment invariably develop resistance to the drugs. Known …

Abstract Vagus nerve stimulation (VNS) has been shown to improve left ventricular function
and survival in rats with acute myocardial infarction (AMI), and this maneuver has also been
adopted clinically for the treatment of patients with chronic heart failure (CHF). Recent in …

Abstract Exercise training is a well-known coadjuvant in heart failure treatment; however, the
molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary
cause, heart failure is often preceded by two distinct phenomena: mitochondria …

Abstract Aerobic exercise training (AET) is an important mechanical stimulus that modulates
skeletal muscle protein turnover, leading to structural rearrangement. Since the ubiquitin-
proteasome system (UPS) and calpain system are major proteolytic pathways involved in …

Abstract Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by
the expansion of a CAG repeat encoding a polyglutamine tract in Ataxin-1 (ATXN1). Both WT
and mutant ATXN1 interact with 14-3-3 proteins, and 14-3-3 overexpression stabilizes …

↵1 To whom correspondence should be addressed: Dept. of Biomedical Informatics, Ohio State
University, 460 W. 12th Ave., Columbus, OH 43210. Tel.: 614-292-0523; E-mail:
Jeffrey.Parvin{at}osumc.edu. … Background: The SUMO system is involved in …

Abstract Transmembrane adenylyl cyclase (AC) generates a cAMP pool within the
subplasma membrane compartment that strengthens the endothelial cell barrier. This cAMP
signal is steered toward effectors that promote junctional integrity and is inactivated before …