Recent Citations

Abstract Recent studies demonstrate that ketamine, a fast-acting antidepressant, rapidly
activates the mammalian target of rapamycin (mTOR) and increases synaptogenesis in the
prefrontal cortex. Because of the side-effect and abuse potential of ketamine we are …

Abstract Paternal care is rare among mammals, occurring in≈ 6% of species. California
mice (Peromyscus californicus) are unusual; fathers participate extensively in raising their
young and display the same components of parental care as mothers, with the exception …

Abstract In cerebellar granule (CG) cells and many other neurons, A-type potassium currents
play an important role in regulating neuronal excitability, firing patterns, and activity-
dependent plasticity. Protein biochemistry has identified dipeptidyl peptidase-like protein …

ABSTRACT Infection by virulent strains of Mycobacterium tuberculosis (Mtb) induces a
delayed type hypersensitive (DTH) reaction in all people who may, or may not develop the
tuberculosis disease. Immunization with Mycobacterium bovis, used in the BCG vaccine …

Abstract A variety of mutations in the gene encoding DJ-1 protein cause autosomal
recessive early-onset parkinsonism. Recently, a novel pathogenic homozygous DJ-1
missense mutation resulting in the L10P amino acid substitution was reported. In a …

Abstract Onset of juvenile Type 1 diabetes (T1D) occurs when autoreactive lymphocytes
progressively destroy the insulin-producing beta-cells in the pancreatic Islets of Langerhans.
The increasing lack of insulin and subsequent onset of hyperglycemia results in increased …

Abstract A major barrier to regeneration of CNS axons is the presence of growth-inhibitory
proteins associated with myelin and the glial scar. To identify chemical compounds with the
ability to overcome the inhibition of regeneration, we screened a novel triazine library, …

Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an
important cellular stress response pathway involved in neuroprotection. We previously
screened several natural phytochemicals and identified plumbagin as a novel activator of …

Cerebral ischemia causes blood flow derangements characterized by hyperemia (increased
cerebral blood flow, CBF) and subsequent hypoperfusion (decreased CBF). We previously
demonstrated that protein kinase C delta (δPKC) plays an important role in hippocampal …

Abstract Cognitive impairment is common following traumatic brain injury (TBI), and
neuroinflammatory mechanisms may predispose to the development of neurodegenerative
disease. Apolipoprotein E (apoE) polymorphisms modify neuroinflammatory responses, …

The PYK2 tyrosine kinase is a negative regulator of bone formation, but aside from the
requirement for PYK2 kinase activity there has been little progress toward understanding of
the molecular mechanism involved in this function. To gain insight into the signaling …

The purpose of this study was to investigate the progression of changes in retinal ganglion
cells and optic nerve glia in neurofibromatosis-1 (NF1) genetically-engineered mice with
optic glioma. Optic glioma tumors were generated in Nf1+/− mice lacking Nf1 expression …

Abstract Regulators of G protein signaling (RGS) proteins negatively modulate G protein-
coupled receptor (GPCR) signaling activity by accelerating G protein hydrolysis of GTP,
hastening pathway shutoff. A wealth of data from cell culture experiments using …

Abstract Chlamydia trachomatis infection is currently the most common cause of infection-
related sterility in women. However, it remains largely unknown how uterine epithelial cells
interact with recruited leucocytes in response to C. trachomatis infection in the female …

Although β-catenin/T-cell factor (TCF) (β-CTS) signaling plays multiple critical roles in carcinogenesis
(1, 2), activation of β-CTS by steroid hormones via direct intracellular pathways has not been
identified in prostate cancer (PrCa) cells. Androgens inhibit β-CTS in androgen receptor …

Abstract: Targeting of the vascular endothelium compartment explains, in part, the
therapeutic efficacy of the nonselective β-adrenergic antagonist propranolol against
common endothelial tumors such as hemangiomas. In vitro, the antiangiogenic biological …

Abstract Many transcription factors have important roles in the function and differentiation of
the human pituitary adenomas. Forkhead box gene transcription factor L2, Foxl2, is
expressed during mouse pituitary development and co-localizes with the expression of α- …

Abstract The mammalian CNS contains an abundant, widely distributed population of glial
cells that serve as oligodendrocyte progenitors. It has been reported that these NG2-
immunoreactive cells (NG2+ cells) form synapses and generate action potentials, …

Abstract In adult skeletal muscle, brain-derived neurotrophic factor (BDNF) is expressed in
myogenic progenitors known as satellite cells. To functionally address the role of BDNF in
muscle satellite cells and regeneration in vivo, we generated a mouse in which BDNF is …

BACKGROUND: Skeletal muscle sodium channel (Nav1. 4) expression in border zone
myocardium increases action potential upstroke velocity in depolarized isolated tissue.
Because resting membrane potential in the 1-week canine infarct is reduced, we …

Background Circadian disruptions through frequent transmeridian travel, rotating shift work,
and poor sleep hygiene are associated with an array of physical and mental health
maladies, including marked deficits in human cognitive function. Despite anecdotal and …

Abstract Rationale: Human CD34+ cells have been used in clinical trials for treatment of
myocardial infarction (MI). However, it is unknown how long the CD34+ cells persist in
hearts, whether the improvement in cardiac function is sustained, or what are the …

Background: Activated hepatic stellate cells (HSC) and other fibrogenic cell types are
frequently found around hepatocellular carcinoma. It is unknown whether hepatocarcinoma
cells regulate the biological functions of HSC. Aims: This study aimed to investigate the …

Human embryonic stem cell (ESC)–derived neural cells are a potential cell source for neural
tissue regeneration. Understanding the biochemical and biophysical regulation of neural
differentiation and axon growth will help us develop cell therapies and bioactive scaffolds. …

Targeted gene therapy can potentially minimize undesirable off-target toxicity due to specific
delivery. Neuron-specific gene delivery in the central nervous system is challenging
because neurons are non-dividing and also outnumbered by glial cells. One approach is …

Rapid and multiplexed measurement is vital in the detection of food-borne pathogens. While
highly specific and sensitive, traditional immunochemical assays such as enzyme-linked
immunosorbent assays (ELISAs) often require expensive read-out equipment (eg …

Q8 Heike Bähre a, b, 1, Christina Hartwig a, 1, Antje Munder c, 1, Sabine Wolter a, Tane Stelzer
a, Bastian Schirmer a, Ulrike Beckert a, Dara W. Frank d, Burkhard Tümmler c, Volkhard Kaever
a, b, Roland Seifert a, * a Institute of Pharmacology, Hannover Medical School, D-30625 …

Abstract Capsular polysaccharides are important factors in bacterial pathogenesis and have
been the target of a number of successful vaccines. Francisella tularensis has been
considered to express a capsular antigen but none has been isolated or characterized. …

Copyright:© Anderson, Frank. This is an open-access article distributed under the terms of
the Creative Commons Attribution License, which permits unrestricted use, distribution, and
reproduction in any medium, provided the original author and source are credited.