Recent Citations

Citations: 2010 – 2016

Model of Alzheimer’s Disease

CA Colton, MP Vitek, J Davis, WE VanNostrand – US Patent 8,993,833, 2015
A modified non-human warm-blooded vertebrate animal in which a biologically active
human APP polypeptide is expressed, and in which function of its inducible Nitric Oxide
Synthase (iNOS) protein is reduced as compared to a non-modified animal, methods of

Detection, screening, and diagnosis of HPV-associated cancers

S Cheng – US Patent 8,968,995, 2015
Embodiments of the invention provide methods, polyclonal antibodies, monoclonal
antibodies, assays, and kits for detecting HPV infection, including infection by various HPV
genotypes, early and/or late HPV-associated or HPV-specific proteins or antibodies.

Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody

M Ahmed, M Cheng, IY Cheung, NKV Cheung – OncoImmunology, 2015
Bispecific antibodies (BsAbs) have proven highly efficient T cell recruiters for cancer
immunotherapy by virtue of one tumor antigen-reactive single chain variable fragment (scFv)
and another that binds CD3. In order to enhance the antitumor potency of these tandem

Impaired GAPDH?induced mitophagy contributes to the pathology of Huntington’s disease

S Hwang, MH Disatnik, D Mochly?Rosen – EMBO molecular medicine, 2015
Abstract Mitochondrial dysfunction is implicated in multiple neurodegenerative diseases. In
order to maintain a healthy population of functional mitochondria in cells, defective
mitochondria must be properly eliminated by lysosomal machinery in a process referred to

Increased clearance of reactive aldehydes and damaged proteins in hypertension-induced compensated cardiac hypertrophy: impact of exercise training

JC Campos, T Fernandes, LRG Bechara, NA Paixão… – Oxidative medicine and …, 2015
Background. We previously reported that exercise training (ET) facilitates the clearance of
damaged proteins in heart failure. Here, we characterized the impact of ET on cardiac
protein quality control during compensated ventricular hypertrophy in spontaneously

MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase

JHE Mäki-Jouppila, S Pruikkonen, MB Tambe… – Molecular oncology, 2015
Abstract The let-7 microRNA (miRNA) family has been implicated in the regulation of diverse
cellular processes and disease pathogenesis. In cancer, loss-of-function of let-7 miRNAs
has been linked to tumorigenesis via increased expression of target oncogenes.

Biphasic effects of luteolin on interleukin-1?-induced cyclooxygenase-2 expression in glioblastoma cells

S Lamy, PL Moldovan, AB Saad, B Annabi – Biochimica et Biophysica Acta (BBA)- …, 2015
Abstract Success in developing therapeutic approaches to target brain tumor-associated
inflammation in patients has been limited. Given that the inflammatory microenvironment is a
hallmark signature of solid tumor development, anti-inflammatory targeting strategies have

CCR9-mediated signaling through ?-catenin and identification of a novel CCR9 antagonist

S Lee, EL Heinrich, L Li, J Lu, AH Choi, RA Levy… – Molecular oncology, 2015
Abstract Elevated levels of chemokine receptor CCR9 expression in solid tumors may
contribute to poor patient prognosis. In this study, we characterized a novel CCR9-mediated
pathway that promotes pancreatic cancer cell invasion and drug resistance, indicating that

Exercise training attenuates age-dependent elevation of angiotensin II type 1 receptor and Nox2 signaling in the rat heart

Y Lee, HB Kwak, J Hord, JH Kim, JM Lawler – Experimental gerontology, 2015
Abstract Fibrosis of the aging heart impedes cardiac function and increases the risk of
arrhythmias and heart disease. Previously, we demonstrated that exercise-induced
reduction of collagen I in the aging heart was linked to a suppression of oxidative stress

Myosin phosphatase isoforms and related transcripts in the pig coronary circulation and effects of exercise and chronic occlusion

X Zheng, CL Heaps, SA Fisher – Microvascular research, 2015
Abstract Myosin phosphatase (MP) is a key target of signaling pathways that regulate
smooth muscle tone and blood flow. Alternative splicing of MP targeting subunit (MYPT1)
exon 24 (E24) generates isoforms with variable presence of a C-terminal leucine zipper (

Pseudomonas aeruginosa toxin ExoY, a cUMP/cGMP-producing nucleotidyl cyclase My Citations

C Wölfel, DW Frank, S Wolter, V Kaever, R Seifert – NAUNYN-SCHMIEDEBERGS …, 2010
Pseudomonas aeruginosa toxin ExoY, a cUMP/cGMP-producing nucleotidyl cyclase.
C Woelfel, DW Frank, S Wolter, V Kaever, R Seifert NAUNYN-SCHMIEDEBERGS

The Pseudomonas Aeruginosa Exotoxin Y Impairs Microtubule Assembly In Pulmonary Microvascular Endothelial Eells My Citations

N Prasain, J Prater, M Alexeyev, B Zhu, S Sayner… – Am J Respir Crit Care Med, 2011
Rationale: Pseudomonas aeruginosa is an opportunistic pathogen that causes acute and
chronic pulmonary infections. During pulmonary infection, Pseudomonas uses a type III
secretion system (T3SS) to transfer an adenylyl cyclase termed ExoY to the cytoplasm of

The Pseudomonas AerugINOSa Exotoxin Y Impairs Endothelial Cell Proliferation, Angiogenesis, And Vascular Repair Following Lung Injury My Citations

CD Ochoa, MJ Robson, C Zhou, KA Morrow… – Am J Respir Crit Care Med, 2013
Rationale: ExoY is a Pseudomonas aeruginosa toxin that is introduced into host cells
through the type 3 secretion system (T3SS). Once inside the host cell cytoplasm ExoY
generates cyclic nucleotides that cause tau phosphorylation and microtubule breakdown.

The effector protein ExoY secreted by Pseudomonas aeruginosa augments the inflammatory reaction in the respiratory tract of mice My Citations

J Rothschuh, A Munder, B Tuemmler, D Frank… – NAUNYN- …, 2015
The effector protein ExoY secreted by Pseudomonas aeruginosa augments the
inflammatory reaction in the respiratory tract of mice. J Rothschuh, A Munder, B
Tuemmler, D Frank, R Seifert, C Hartwig NAUNYN-SCHMIEDEBERGS

Pseudomonas aeruginosa infection causes endothelial cell Tau aggregation: evidence for an endothelial tauopathy (1176.5) My Citations

K Morrow, C Ochoa, M Alexeyev, D Frank, R Balczon… – The FASEB Journal, 2014
Abstract Our laboratory recently demonstrated that Pseudomonas aeruginosa exoenzyme Y
(ExoY) stimulates Tau hyperphosphorylation and insolubility-hallmarks of a “Tauopathy”.
Unlike neurodegenerative Tauopathies, we did not observe formation of Tau aggregates

Pseudomonas AerugINOSa Impairs The Activation Of Store Operated Calcium Entry Via Microtubule-Associated Protein 6 My Citations

CD Ochoa, TC Stevens, M Alexeyev, DW Frank… – Am J Respir Crit Care Med, 2012
Milwaukee, WI causes bronchopneumonia that can progress to acute lung injury. interacts
with and disrupts the Pseudomonas aeruginosa P. aeruginosa lung capillary endothelial cell
barrier resulting in alveolar edema and hemorrhage. uses a type III secretion system (

ExoY from Pseudomonas aeruginosa, a preferential guanylyl and uridylyl cyclase (610.2) My Citations

R Seifert, U Beckert, D Frank – The FASEB Journal, 2014
Abstract ExoY from Pseudomonas aeruginosa is injected into host cells via the type III
secretion system (Yahr TL et al., Proc Natl Acad Sci USA 95: 13899 (1998)). ExoY is
structurally similar to CyaA from Bordetella pertussis and edema factor (EF) from Bacillus

Francisella tularensis Mutagenesis of My Citations

C Zahrt, DW Frank
MATERIALS AND METHODS Bacterial strains, plasmids, and growth conditions. All
bacterial strains and plasmids used in this study are listed in Table 1. F. tularensis LVS was
routinely grown at 37 C in modified Mueller-Hinton (MH) broth or on agar (Difco

Pseudomonas aeruginosa Exoenzymes U and Y Induce a Transmissible Endothelial Tauopathy My Citations

K Morrow, C Ochoa, R Balczon, L Cauthen, M Alexeyev… – The FASEB Journal, 2015
Abstract Here, we tested the hypothesis that Pseudomonas aeruginosa type 3 secretion
system effectors ExoY and ExoU induce endothelial tau oligomerization and release,
causing transmissible cytotoxicity characteristic of an infectious tauopathy. Both the

Cross Kingdom Activators of Five Classes of Bacterial Effectors My Citations

DM Anderson, JB Feix, DW Frank – PLoS Pathog, 2015
Copyright:© 2015 Anderson et al. This is an open access article distributed under the terms
of the Creative Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are credited

Targets Of Subplasma Membrane Versus Cytosolic Adenylyl Cyclase Activity Demonstrate The Bidirectional Nature Of The CAMP Diffusion Barricade That Maintains … My Citations

R Balczon, D Frank, D Cooper, T Stevens, S Sayner – Am J Respir Crit Care Med, 2010
RATIONALE: Strongly adherent pulmonary microvascular endothelial cells (PMVECs)
interact to form the pulmonary capillary barrier, necessary to maintain efficient gas exchange
in the lung. Transmembrane adenylyl cyclase activity generates cAMP restricted to the

Reproducible and Quantitative Model of Infection of Dermacentor variabilis with the Live Vaccine Strain of Francisella tularensis My Citations

J Coburn, T Maier, M Casey, L Padmore, H Sato… – Applied and environmental …, 2015
ABSTRACT Pathogen life cycles in mammalian hosts have been studied extensively, but
studies with arthropod vectors represent considerable challenges. In part this is due to the
difficulty of delivering a reproducible dose of bacteria to follow arthropod-associated

Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells

CH Chuang, D Yang, G Bai, A Freeland, SC Pruitt… – Nucleic acids research, 2012
Abstract The MiniChromosome Maintenance 2-7 (MCM2-7) complex provides essential
replicative helicase function. Insufficient MCMs impair the cell cycle and cause genomic
instability (GIN), leading to cancer and developmental defects in mice. Remarkably,

Expression profile and mitochondrial colocalization of Tdp1 in peripheral human tissues

HK Fam, MK Chowdhury, C Walton, K Choi… – Journal of molecular …, 2013
Abstract Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes
blocked 3? ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with
axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of

Astrocytic TDP-43 pathology in Alexander disease

AK Walker, CMLP Daniels, JE Goldman… – The Journal of …, 2014
Abstract Alexander disease (AxD) is a rare neurodegenerative disorder characterized
pathologically by the presence of eosinophilic inclusions known as Rosenthal fibers (RFs)
within astrocytes, and is caused by dominant mutations in the coding region of the gene

ANG4043, a Novel Brain-Penetrant Peptide–mAb Conjugate, Is Efficacious against HER2-Positive Intracranial Tumors in Mice

A Regina, M Demeule, S Tripathy, S Lord-Dufour… – Molecular cancer …, 2015
Abstract Anti-HER2 monoclonal antibodies (mAb) have been shown to reduce tumor size
and increase survival in patients with breast cancer, but they are ineffective against brain
metastases due to poor brain penetration. In previous studies, we identified a peptide,

Sexual experience promotes adult neurogenesis in the hippocampus despite an initial elevation in stress hormones

B Leuner, ER Glasper, E Gould – PLoS One, 2010
Abstract Aversive stressful experiences are typically associated with increased anxiety and a
predisposition to develop mood disorders. Negative stress also suppresses adult
neurogenesis and restricts dendritic architecture in the hippocampus, a brain region

Ubiquitin activates patatin-like phospholipases from multiple bacterial species My Citations

DM Anderson, H Sato, AT Dirck, JB Feix, DW Frank – Journal of bacteriology, 2015
ABSTRACT Phospholipase A 2 enzymes are ubiquitously distributed throughout the
prokaryotic and eukaryotic kingdoms and are utilized in a wide array of cellular processes
and physiological and immunological responses. Several patatin-like phospholipase

cCMP and cUMP occur in vivo My Citations

H Bähre, C Hartwig, A Munder, S Wolter, T Stelzer… – … and biophysical research …, 2015
Abstract Mammalian cells contain the cyclic pyrimidine nucleotides cCMP and cUMP. It is
unknown whether these tentative new second messenger molecules occur in vivo. We used
high performance liquid chromatography quadrupole tandem mass spectrometry to

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