Recent Citations

Citations: 2010 – 2016

Exercise training restores cardiac protein quality control in heart failure

Abstract Exercise training is a well-known coadjuvant in heart failure treatment; however, the
molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary
cause, heart failure is often preceded by two distinct phenomena: mitochondria

Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) A DUAL …

A Goyal, N Pal, M Concannon, M Paul, M Doran… – Journal of Biological …, 2011
Abstract Endorepellin, the C-terminal module of perlecan, negatively regulates
angiogenesis counter to its proangiogenic parental molecule. Endorepellin (the C-terminal
domain V of perlecan) binds the α2β1 integrin on endothelial cells and triggers a signaling

The antiprogestin Lonaprisan inhibits breast cancer cell proliferation by inducing p21 expression

L Busia, H Faus, J Hoffmann, B Haendler – Molecular and cellular endocrinology, 2011
The ovarian steroid hormone progesterone is essential for normal mammary gland
physiology but may also play a role in breast cancer. Highly potent and selective
antiprogestins may therefore represent a new treatment option for this disease. Here we

Freeze-thaw stress of Alhydrogel® alone is sufficient to reduce the immunogenicity of a recombinant hepatitis B vaccine containing native antigen

T Clapp, MW Munks, R Trivedi, UB Kompella… – Vaccine, 2014
Abstract Preventing losses in vaccine potency due to accidental freezing has recently
become a topic of interest for improving vaccines. All vaccines with aluminum-containing
adjuvants are susceptible to such potency losses. Recent studies have described

Regulator of calmodulin signaling knockout mice display anxiety‐like behavior and motivational deficits

MM Davis, P Olausson, P Greengard, JR Taylor… – European Journal of …, 2012
Abstract Regulator of calmodulin (CaM) signaling (RCS), when phosphorylated by protein
kinase A (PKA) on Ser55, binds to CaM and inhibits CaM-dependent signaling. RCS
expression is high in the dorsal striatum, nucleus accumbens and amygdala, suggesting

Evaluation of influenza-specific humoral response by microbead array analysis

Y Keynan, T Bodnarchuk, S Wayne, Y Li, KR Fowke – Canadian Journal of …, 2011
RATIONALE: Quantitation and determination of antigen specificity of systemic and mucosal
immune responses to influenza vaccination is beneficial for future vaccine development.
Previous methods to acquire this information were costly, time consuming and sample

Orthobunyavirus entry into neurons and other mammalian cells occurs via clathrin-mediated endocytosis and requires trafficking into early endosomes

BS Hollidge, NB Nedelsky, MV Salzano, JW Fraser… – Journal of virology, 2012
ABSTRACT La Crosse virus (LACV) is a leading cause of pediatric encephalitis and aseptic
meningitis in the midwestern and southern United States, where it is considered an
emerging human pathogen. No specific therapies or vaccines are available for LACV or

IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer

P Kachroo, MH Lee, L Zhang, F Baratelli, G Lee… – Journal of Experimental & …, 2013
Background Interleukin-27 signaling is mediated by the JAK-STAT pathway via activation of
STAT1 and STAT3, which have tumor suppressive and oncogenic activities, respectively.
Epithelial–mesenchymal transition (EMT) and angiogenesis are key processes in

TgGRA23, a novel Toxoplasma gondii dense granule protein associated with the parasitophorous vacuole membrane and intravacuolar network

T Masatani, T Matsuo, T Tanaka, MA Terkawi, EG Lee… – Parasitology international, 2013
Toxoplasma gondii is an intracellular protozoan parasite, which relies on a specialized
compartment, the parasitophorous vacuole (PV), to survive within host cells. Dense granules
within the parasite release a large variety of proteins to maintain the integrity of the

SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic

GJJ Boink, DH Lau, IN Shlapakova, EA Sosunov… – Cardiovascular research, 2012
Aims Reentry accounts for most life-threatening arrhythmias, complicating myocardial
infarction, and therapies that consistently prevent reentry from occurring are lacking. In this
study, we compare antiarrhythmic effects of gene transfer of green fluorescent protein (

Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease Incidence of Ventricular Tachycardia in Mice.

KA Prestia, EA Sosunov, EP Anyukhovsky… – Front Physiol, 2011
Increasing connexin43 (Cx43) gap junctional conductance as a means to improve cardiac
conduction has been proposed as a novel antiarrhythmic modality. Yet, transmission of
molecules via gap junctions may be associated with increased infarct size. To determine

Transforming growth factor β1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer- …

X Liu, YS Piao, JT Arnold – Carcinogenesis, 2011
Abstract Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone
(DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue
model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (

A “two-hit” hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport

GS Pesiridis, K Tripathy, S Tanik, JQ Trojanowski… – Journal of Biological …, 2011
Abstract Carboxyl-terminal fragments (CTFs) of TDP-43 aggregate to form the diagnostic
signature inclusions of frontotemporal lobar degeneration and amyotrophic lateral sclerosis,
but the biological significance of these CTFs and how they are generated remain

EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer’s disease

Y Ferrer‐Acosta, EN Rodríguez‐Cruz, F Orange… – Journal of neurochemistry, 2013
Abstract EFhd2 is a conserved calcium-binding protein, abundant within the central nervous
system. Previous studies identified EFhd2 associated with pathological forms of tau proteins
in the tauopathy mouse model JNPL3, which expresses the human tau P301L mutant.

Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is Sirt1-independent

B Annabi, S Lord-Dufour, A Vézina, R Béliveau – Drug Target Insights, 2012
Abstract The occurrence of a functional relationship between the release of
metalloproteinases (MMPs) and the expression of cyclooxygenase (COX)-2, two inducible
pro-inflammatory biomarkers with important pro-angiogenic effects, has recently been

Increased propensity for cell death in diabetic human

R Chitwood, AP Kypson – Am J Physiol Heart Circ Physiol, 2011
METHODS Clinical data and patient demographics. The University and Medical Center
Institutional Review Board approved all aspects of patient recruitment and informed consent
for this study. Cohorts evaluated were diabetic and nondiabetic patients at the East

Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells

S Winsel, A Sommer, J Eschenbrenner, K Mittelstaedt… – PloS one, 2011
Abstract Sagopilone, an optimized fully synthetic epothilone, is a microtubule-stabilizing
compound that has shown high in vitro and in vivo activity against a broad range of human
tumor models. We analyzed the differential mechanism of action of sagopilone in non-

Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: Benefits of Alda-1

KMS Gomes, LRG Bechara, VM Lima, MAC Ribeiro… – International journal of …, 2015
Methods Here we characterized cardiac ALDH2 activity and expression, lipid peroxidation, 4-
hydroxy-2-nonenal (4-HNE) adduct formation, glutathione pool and mitochondrial energy
metabolism and H 2 O 2 release during the 4 weeks after permanent left anterior

Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid

T Wu, Y Ye, SY Min, J Zhu, E Khobahy, J Zhou, M Yan… – Arthritis & Rheumatology, 2014
Objective Current treatment options for lupus are far from optimal. Previously, we reported
that phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin, MEK-1/ERK-1, 2,
p38, STAT-3, STAT-5, NF-κB, multiple Bcl-2 family members, and various cell cycle

Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior

JM Dwyer, JG Maldonado-Avilés, AE Lepack… – Proceedings of the …, 2015
Abstract Current treatments for major depressive disorder (MDD) have a time lag and are
ineffective for a large number of patients. Development of novel pharmacological therapies
requires a comprehensive understanding of the molecular events that contribute to MDD

Combination Treatment with Apricoxib and IL-27 Enhances Inhibition of Epithelial-Mesenchymal Transition in Human Lung Cancer Cells through a STAT1 Dominant …

MH Lee, P Kachroo, PC Pagano, J Yanagawa… – Journal of cancer science & …, 2014
Background The cyclooxygenase 2 (COX-2) pathway has been implicated in the molecular
pathogenesis of many malignancies, including lung cancer. Apricoxib, a selective COX-2
inhibitor, has been described to inhibit epithelial-mesenchymal transition (EMT) in human

Treatment of peritoneal carcinomatosis with intraperitoneal administration of Ad-hARF

BR Rajeshkumar, S Paliwal, L Lambert, SR Grossman… – Journal of Surgical …, 2015
Background Peritoneal dissemination of cancer is a terminal condition with limited
therapeutic options. Because the peritoneal cavity is a single enclosed space, regional
treatment approaches for isolated peritoneal cancrinomatosis are appealing. There is a

Expression of skeletal muscle sodium channel (Nav1. 4) or connexin32 prevents reperfusion arrhythmias in murine heart

EP Anyukhovsky, EA Sosunov, YN Kryukova, K Prestia… – Cardiovascular research, 2011
Aims Acute myocardial ischaemia induces a decrease in resting membrane potential [which
leads to reduction of action potential (AP) V max] and intracellular acidification (which closes
gap junctions). Both contribute to conduction slowing. We hypothesized that ventricular

Tetracycline derivative minocycline inhibits autophagy and inflammation in concanavalin-a-activated human hepatoma cells

M Desjarlais, J Pratt, A Lounis, C Mounier, K Haidara… – Gene regulation and …, 2014
Abstract Inhibition of soluble matrix metalloproteinase (MMP) activity is among the non-
antibiotic cellular effects exerted by the anti-inflammatory tetracycline derivative minocycline.
The impact of minocycline on the signal transduction functions of membrane-bound MMPs

Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells

S Martino, R Tiribuzi, E Ciraci, G Makrypidi… – The international journal of …, 2011
The identity of biochemical players which underpin the commitment of CD34+ hematopoietic
stem cells to immunogenic or tolerogenic dendritic cells is largely unknown. To explore this
issue, we employed a previously established cell-based system amenable to shift

Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer

K Krysan, X Cui, BK Gardner, KL Reckamp, X Wang… – Am J Transl Res, 2013
Abstract: Purpose: The EGFR tyrosine kinase inhibitors (TKIs) demonstrate efficacy in
NSCLC patients whose tumors harbor activating EGFR mutations. However, patients who
initially respond to EGFR TKI treatment invariably develop resistance to the drugs. Known

Optimizing the parameters of vagus nerve stimulation by uniform design in rats with acute myocardial infarction

SS Kong, JJ Liu, TC Hwang, XJ Yu, M Zhao, M Zhao… – PloS one, 2012
Abstract Vagus nerve stimulation (VNS) has been shown to improve left ventricular function
and survival in rats with acute myocardial infarction (AMI), and this maneuver has also been
adopted clinically for the treatment of patients with chronic heart failure (CHF). Recent in

Exercise training restores cardiac protein quality control in heart failure

JC Campos, BB Queliconi, PMM Dourado, TF Cunha… – PLoS One, 2012
Abstract Exercise training is a well-known coadjuvant in heart failure treatment; however, the
molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary
cause, heart failure is often preceded by two distinct phenomena: mitochondria

Aerobic exercise training upregulates skeletal muscle calpain and ubiquitin-proteasome systems in healthy mice

TF Cunha, JBN Moreira, NA Paixão, JC Campos… – Journal of applied …, 2012
Abstract Aerobic exercise training (AET) is an important mechanical stimulus that modulates
skeletal muscle protein turnover, leading to structural rearrangement. Since the ubiquitin-
proteasome system (UPS) and calpain system are major proteolytic pathways involved in

Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3ε haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration

P Jafar-Nejad, CS Ward, R Richman, HT Orr… – Proceedings of the …, 2011
Abstract Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by
the expansion of a CAG repeat encoding a polyglutamine tract in Ataxin-1 (ATXN1). Both WT
and mutant ATXN1 interact with 14-3-3 proteins, and 14-3-3 overexpression stabilizes

Small ubiquitin-like modifier (SUMO) isoforms and conjugation-independent function in DNA double-strand break repair pathways

Y Hu, JD Parvin – Journal of Biological Chemistry, 2014
↵1 To whom correspondence should be addressed: Dept. of Biomedical Informatics, Ohio State
University, 460 W. 12th Ave., Columbus, OH 43210. Tel.: 614-292-0523; E-mail:
Jeffrey.Parvin{at} Background: The SUMO system is involved in

Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity My Citations

SL Sayner, R Balczon, DW Frank, DMF Cooper… – American Journal of …, 2011
Abstract Transmembrane adenylyl cyclase (AC) generates a cAMP pool within the
subplasma membrane compartment that strengthens the endothelial cell barrier. This cAMP
signal is steered toward effectors that promote junctional integrity and is inactivated before

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